Allogeneic haematopoietic stem cell donation and transplantation
across the MHC class I barrier: "Faster is better than more. More is
better than less".
Heemskerk, M.B.A.
Citation
Heemskerk, M. B. A. (2006, September 28). Allogeneic haematopoietic stem cell donation and transplantation across the MHC class I barrier: "Faster is better than more. More is better than less". Retrieved from https://hdl.handle.net/1887/4578
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4578
8
³The only thing that one really knows about human nature
is that it changes.
Change is the one quality we can predicate of it.
The systems that fail
are those that rely on the permanency of human nature,
and not on its growth and development.”
122
Summary
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124
General Discussion
Merits and pitfalls of research on databases
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Donor patient matching strategies
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127 VHDUFKWLPHVSDQWREHVXEPLWWHG7KHPHGLDQWLPHQHHGHGWR¿QGDGRQRUIRUSDWLHQWV RI 1RUWKZHVW (XURSHDQ RULJLQ GHFUHDVHG IURP PRQWKV WR PRQWKV DQG WKH PHGLDQ WLPHVSDQEHWZHHQWKHVWDUWRIWKHVHDUFKWUDQVSODQWDWLRQGHFUHDVHGIURPPRQWKVWR PRQWKV7KLVKDVUHVXOWHGLQDGHFUHDVHRIWKHSHUFHQWDJHRISDWLHQWVIRUZKRPWKHGRQRU VHDUFK KDG WR EH VWRSSHG EHFDXVH WKH SDWLHQW ZDV QR ORQJHU ¿W IRU WUDQVSODQWDWLRQ IURP SHUFHQWLQWRSHUFHQWLQ$VDUHVXOWSHUFHQWRISDWLHQWV UHFHLYHGDJUDIWFRPSDUHGWRSHUFHQWLQWKHSUHYLRXVSHULRG7KLVLQGLFDWHVWKDWLIWKH VHDUFKWLPHVSDQFDQEHEURXJKWGRZQWRZHHNVWKLVFRXOGOHDGWRDVLJQL¿FDQWLQFUHDVHV of the proportion of patients reaching transplantation and therefore heighten the chances of VXUYLYDOIRUWKHVHSDWLHQWV +RZHYHULWVKRXOGEHQRWHGWKDWD*_`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`0+&PLVPDWFKHVJHQHUDWHPRUHSRVVLELOLWLHVIRUSDWLHQWVZKRODFN DIXOO\PDWFKHGGRQRU&KRRVLQJVXFKDGRQRULQVWHDGRIZDLWLQJIRUWKHIXOO\PDWFKHGRQH FDQVDYHDORWRISUHFLRXVWLPHZKHQWLPHLVVKRUW,QP\RSLQLRQDQLQFUHDVHRIHI¿FLHQF\ LQWKHZKROHGRQDWLRQDQGWUDQVSODQWDWLRQSURFHVVZLOOUHVXOWLQDFRQVLGHUDEO\KLJKHUFKDQFH RISDWLHQWVXUYLYDO
128
Reference List
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