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Allogeneic haematopoietic stem cell donation and transplantation across the MHC class I barrier: "Faster is better than more. More is better than less".

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Allogeneic haematopoietic stem cell donation and transplantation

across the MHC class I barrier: "Faster is better than more. More is

better than less".

Heemskerk, M.B.A.

Citation

Heemskerk, M. B. A. (2006, September 28). Allogeneic haematopoietic stem cell donation

and transplantation across the MHC class I barrier: "Faster is better than more. More is better than less". Retrieved from https://hdl.handle.net/1887/4578

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4578

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1 General Introduction

ALLOGENEIC HAEMATOPOIETIC STEM CELL DONATION

AND TRANSPLANTATION

ACROSS THE MHC CLASS I BARRIER:

FASTER IS BETTER THAN MORE

MORE IS BETTER THAN LESS

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Preface 9

Chapter 1

General Introduction 10

Chapter 2

How to improve the search for an unrelated

haematopoietic stem cell donor. Faster is better than more! 32

Chapter 3

The importance of identifying a back-up donor

for unrelated stem cell transplantation 52

Chapter 4

The HLAMatchmaker algorithm is not a suitable tool to predict

the alloreactive cytotoxic T lymphocyte response in vitro 62

Chapter 5

The HistoCheck algorithm does not predict T cell

alloreactivity in vitro. 74

Chapter 6

Allogeneic MHC class I molecules with numerous sequence

differences do not elicit a CTL response. 80

Chapter 7

Acceptable MHC class I mismatches in haematopoietic

stem cell transplantation. 100

Chapter 8

Summary and General Discussion 120

Chapter 9

Samenvatting 130

Abbreviations 137

Curriculum vitae 139

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