Following that, he was included in the Egyptian Specialist Register for Internal Medicine

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CURRICULUM VITAE

Mohamed Mohamed Thabet Okily was born in the 24^th of May 1975 in Abnüb, Egypt. In 1992 he was awarded his high school diploma from Abnoub high school, Assiut, Egypt (A+

level). Between 1992 and 1999 the author studied medicine in the Faculty of Medicine, Assiut University, Egypt where he graduated after finishing his internship year (cum laude).

In March 2000 the author began his residency training in Internal Medicine in the department of Internal Medicine, Assiut University Hospital, Egypt and in 2004 he obtained his Master degree in Internal Medicine from Assiut University after defending his Master thesis

“Anticardiolipin antibodies in acute rheumatic fever and chronic rheumatic heart disease”

under supervision of professors N.Tawfik and M.Kamel. Following that, he was included in the Egyptian Specialist Register for Internal Medicine. From June 2004 he has been working as a Specialist and Associate Lecturer of Internal Medicine in Assiut University Hopsital, Egypt. Since 2000 the author was deeply involved in clinical research, medical education and clinical tasks. The author showed special interest in Rheumatology.

Between 2006 and 2010 the author worked as a clinical research fellow in Leiden University Medical Center, the Netherlands. Currently the author is still affiliated with and working for the department of Internal Medicine & Rheumatology Unit, Assiut University Hospital, Egypt as an Associate Lecturer and Specialist of Internal Medicine.

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LIST OF PUBLICATIONS Book Chapters

Mohamed M. Thabet and T. Huizinga, chapter 56 “Dapsone, penicillamine, thalidomide, bucillamine, and the tetracyclines” in “RHEUMATOLOGY 5th edition 2011 by Hochberg et al.” ISBN: 9780323065511.

Mohamed M. Thabet and T. Huizinga, chapter 47 “Other drugs in Rheumatic Disease” in

“RHEUMATOLOGY 4th edition 2008 by Hochberg et al.” ISBN: 0323033644.

Articles

Kochi Y, Thabet M, Suzuki A, Okada Y, Daha NA, Toes RE, Huizinga TW, Myouzen K, Kubo M, Yamada R, Nakamura Y, Yamamoto K. PADI4 polymorphism predisposes male smokers to rheumatoid arthritis.Ann Rheum Dis. 2011 Mar;70(3):512.

Marques R.B.^#, Thabet M.^#, White S.J., Houwing-Duistermaat J.J., Bakker A.M., Hendriks G.J., Zhernakova A., Huizinga, T.W., van der Helm-van Mil A.H., Toes R.E. Genetic Variation of the Fc Gamma Receptor 3B Gene and Association with Rheumatoid Arthritis.

PLoS One. 2010 Oct 5;5(10). pii: e13173.

# Equal contribution

Damjanovska L^#, Thabet M^#, Levarth EW, Stoeken-Rijsbergen G, van der Voort EI, Toes RE, Huizinga TW, van der Helm-van Mil AH. Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis. Ann Rheum Dis. 2010 Apr;69(4):730-2.

# Equal contribution

Thabet M, Huizinga TW, Marques RB, Stoeken-Rijsbergen G, Bakker AM, Kurreeman FA, White S, Toes RE, van der Helm-van Mil AH. The contribution of Fc gamma receptor IIIA

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gene 158V/F polymorphism and copy number variation to the risk of ACPA positive rheumatoid arthritis. Ann Rheum Dis. 2009 Nov;68(11):1775-80.

Thabet M, Huizinga TWJ, van der Heijde D, van der Helm-van Mil AHM. “The prognostic value of baseline erosions in undifferentiated arthritis”. Arthritis Res Ther. 2009 Oct 15;11(5):R155.

Thabet M, Wesoly J, Slagboom PE, Toes RE, Huizinga TW. FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians.

Ann Rheum Dis. Jun;66(6):803-6.

Wesoly J, Hu X, Thabet M, Chang M, Uh H, Allaart CF, Toes RE, Houwing-Duistermaat JJ, Begovich AB, Huizinga TW. The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population. Rheumatology (Oxford). 2007 Apr;46(4):617-21.

Thabet M, Huizinga TW. Drug evaluation: Apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis. Curr Opin Investig Drugs. 2006 Nov;7(11):1014-9.

Theses

Master’s Thesis (2004): "Anticardiolipin antibodies in acute rheumatic fever and chronic rheumatic heart disease" Supervisors Prof. Dr. N. Tawfik & Prof. Dr M. Kamel.

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DANKWOORD

I would like to sincerely thank everyone who, in one way or another, contributed to the creation and completion of this thesis.

To start with, I would like to thank Professor Tom Huizinga, Professor Rene Toes, and Dr.

Annette van der Helm for being my mentors. Tom, I admire your marvellous enthusiasm for work and collaboration which gave me the chance to be here in the LUMC to start my fellowship and I do appreciate your continuous support which led me to complete my thesis.

Rene, it was always a pleasure to have you around during all the meetings and discussions.

Your critical approach and valuable remarks were always a good way of brain storming and always improved our research. Annette, thanks for always being available to reply my queries and your meticulous yet very quick and remarkable feedback. I want to express my gratitude to my Egyptian professors who always have been supporting, teaching and guiding me especially Professor Nashwa Tawfik and Professor Mahmoud Ashry.

Moving to the Netherlands to start my fellowship in the Department of Rheumatology in LUMC was a great adventure. I have spent some great years and gained a lot of scientific and life experiences. I must admit that life was not easy at sometimes, but what made it fun to be here was the good company of my colleagues especially those of room C1-45 and C1-46. I will never forget our funny yet productive conversations and discussions, support for each other both in work as well as personal related matters, and the best of all our lunch outs.

Hopefully I won’t forget anybody, Michael, Onno, Robert, Sjoerd, Melek, Naomi, Jessica, Karen, Emalie, Rosanne, Linda, Diane, Rosaline, Angga, and Wing-Yee.

The lab group, thank you all, I have learned a lot from you all. Rute, thanks for your active and thorough collaboration and help. Joris, Andrea, Gerrie, Aleida, Nivine, Ellen, Hanan, and everyone else thank you very much for your help and very friendly attitude. Stefan, you were really helpful in the methodology and design of gene copy number articles even when you moved to Australia, thanks for that. Jeanine, thank you, your help with statistics were pivotal

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to many of the manuscripts in this thesis. Not to forget the people of the staff-centrum, Hanny, Joyce, Hughine and José thank you all for helping with all the official and paper work.

I would like to express my sincere gratitude and thanks to my friends in Leiden and their families who were and still are like a family to me; Bakr Morsy, Attia Abdelbaki, Ali Marashdeh, Mahmoud Al Saify, Mohamed Ghaly, Umar Ryad, Mohamed Myqias, Ayman Khairy, Ibrahim Bayoumi, Khalid Younes, Taleb Alkurdi and Mohamed Alhissi.

I am also indebted to my entire family in Egypt for always being there for me even during the most difficult times especially my parents for their endless wisdom and continuous support.

Last but not least, my wife Randa, I cannot express how wonderful, supportive and caring you have been. Thanks for always being there for me and thanks for bearing with me through those times. None of this would have been possible without you. And kids, although you were distracting me, I have to admit I enjoyed and still enjoying it, you could always draw smiles on my face.

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