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The handle http://hdl.handle.net/1887/19074 holds various files of this Leiden University dissertation.

Author: Suwannalai, Parawee

Title: ACPA response in evolution of rheumatoid arthritis

Issue Date: 2012-06-13

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Acknowledgements 99

ACknowledGements

I would like to express my sincere gratitude to Prof. Dr. Huizinga for introducing me in the PhD training program in the LUMC, and also to Prof. Dr. Toes and Dr.

Leendert Trouw for the continuous support of my PhD study and research, for their patience, motivation, enthusiasm, and immense knowledge.

Also I would like to thank Dr. Monkol and Prof. Suchela from Thailand for giving me a chance to be here for training and I also thank Ramathibodi Hospital for the grant.

I would also like to express my appreciation to Nivine for practical work in the lab, Linda for working in the freezer and Hanane for being a good companion in my hard times.

Moreover, I would like to thank our collaborators within the LUMC, Maarten van Tol and Els Jol-van der Zijde from the department of Pediatrics, Manfred Wuhrer and Caroline Koeleman from the Parasitology for sharing their knowl- edge and technical support. Within the Netherlands I also highly appreciated the collaboration with Lotte van de Stadt, Karin Britsemmer and Dirk-Jan van Schaardenburg from the JBI|READE. Also the very pleasant collaboration with colleagues from around the world, including Helga Radner, Günter Steiner from Vienna, Austria and Hani El-Gabalawy from Canada was much appreciated!

I thank Rachel, Angga, Wing-yee and James (from Hongkong) for many hot pots and many thanks for my Thai-friends in Leiden (Pui, Dome, Kanchana, Piya, Yos, Sun and Max) to be my second family and for a very nice time we had together.

Importantly, I would like to thank my family for mental support, especially my

mother, who was suffering from rheumatoid arthritis, for inspiring me to be a

rheumatologist.

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Curriculum Vitae 101

CurriCulum vitAe

Parawee Suwannalai was born on 15 Febuary 1975 in Songkla province, Thai-

land. She finished her secondary school education at the Triam Udom Suksa

school, Bangkok, in 1992. She studied in Mahidol University, Bangkok, Thailand

and obtained the degree of Bachelor of Sciences, First class honors Doctor of

Medicine in 1998. Next she went to practice as general practitioner in Sukothai

province, Thailand for 3 years before moving back to Bangkok for resident training

in Internal Medicine department, Ramathibodi Hospital, Mahidol University and

obtained board of Internal Medicine on 2003. Next she was enrolled in fellowship

training program of Allergy Immunology Rheumatology Unit, Internal Medicine

department, Ramathibodi Hospital, Mahidol University, Thailand and obtained

Board of Rheumatology on 2006. Finally, she was promoted to be a staff of Allergy

Immunology Rheumatology Unit of Ramathibodi hospital and she worked in this

position for 2 years before applying for a position in the PhD training program of

the rheumatology department at the Leiden University Medical Center, Leiden,

The Netherlands on 2008. In her PhD training, she was under the supervision of

Prof. Dr. T.W.J. Huizinga, Prof. Dr. R.E.M. Toes and Dr. L.A. Trouw.

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Publications 103

PubliCAtions

1. P. suwannalai, K. Britsemmer, R. Knevel, L.A. van de Stadt, H.U. Scherer, M. Wuhrer, N. Levarht, J.W. Drijfhout, Jol-van der Zijde, M.J.D. van Tol, A.H. Van der Helm-van Mil, D. van Schaardenburg, T.W.J. Huizinga, R.E.M.

Toes, L.A.Trouw. Low avidity anti-citrullinated protein antibodies (ACPA) are associated with higher radiographic progression in rheumatoid arthri- tis. Submitted.

2. P. suwannalai, A. Willemze, L. van Toorn, G. Stoeken-Rijsbergen, N. Le- varht, J.W. Drijfhout, T.W.J. Huizinga, R.E.M. Toes, L.A. Trouw. The fine specificity of Anti- Citrullinated Protein Antibodies (ACPA) IgM is differ- ent from ACPA IgG. Arthritis Res Ther. 2011 Nov 30;13(6):R195.

3. P. suwannalai, L.A. van de Stadt, H. Radner, G. Steiner, H.S. El-Gabalawy, C.M. Jol-van der Zijde, M.J. van Tol, D. van Schaardenburg, T.W.J. Huiz- inga, R.E.M. Toes, L.A.Trouw. Avidity maturation of ACPA in rheumatoid arthritis.

Arthritis and Rheumatism, 2012 May;64(5):1323-8.

4. J. Shi, R. Knevel, P. suwannalai, M.P. van der Linden, G.M.C. Janssen, P.

van Veelen, N.E.Levarht, A.H. van der Helm-van Mil, A. Cerami, T.W.J.

Huizinga, R.E.M. Toes, L.A. Trouw. Auto-antibodies recognizing Carba- mylated proteins are frequently present in sera of patients with Rheuma- toid Arthritis and predict radiological joint damage. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17372-7.

5. P Vananuvat, P suwanalai, S Sungkanuparph, T Limsuwan, P Ngamjan- yaporn, S Janwityanujit. Primary prophylaxis for Pneumocystis jirovecii pneumonia in patients with connective tissue diseases. Semin Arthritis Rheum. 2011 Dec;41(3):497-502.

6. P suwannalai, L.A. Trouw, R. E. M. Toes, T.W. J. Huizinga. Anti-citrullinated protein antibodies (ACPA) in early rheumatoid arthritis. Mod Rheumatol 2011 Feb;22(1):15-20.

7. P suwannalai, H U Scherer, D van der Woude, A Ioan-Facsinay, C M Jol-van

der Zijde, M J D van Tol, J.W. Drijfhout, T.W.J. Huizinga, R.E.M. Toes, L.A.

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104 Publications

Trouw. Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens. Ann Rheum Dis 2011; 70: 373-9.

8. M Vanichapuntu, P Phuekfon, P suwannalai, O Verasertniyom, K Nantiruj, S Janwityanujit. Are anti-citrulline autoantibodies better serum markers for rheumatoid arthritis than rheumatoid factor in Thai population? Rheu- matol Int 2010; 30: 755–759.

9. P suwannalai, P Auethavekiat, U Udomsubpayakul, S Janwityanujit. The infectious profiles of anti-tumor necrosis factor agents in a Thai popula- tion: a retrospective study at the university-based hospital. International Journal of Rheumatic Diseases 2009; 12: 118–124.

10. S Jaovisidha, R Denprechawong, P suwannalai, S Janwityanujit. Asymp-

tomatic Avascular Osteonecrosis of the Hip in New Patients Diagnosed

as Systemic Lupus Erythematosus in Ramathibodi Hospital. J Med Assoc

Thai 2007; 90 (7): 1382-90.

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