University of Groningen
Magnetic Nanoparticles for the Control of Infectious Biofilms
Quan, Kecheng
DOI:
10.33612/diss.170829667
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Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Quan, K. (2021). Magnetic Nanoparticles for the Control of Infectious Biofilms. University of Groningen.
https://doi.org/10.33612/diss.170829667
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Magnetic Nanoparticles
for the Control of Infectious Biofilms
Magnetic Nanoparticles for the Control of Infectious Biofilms
University Medical Center Groningen, University of Groningen
Groningen, The Netherlands
Copyright © 2021 by Kecheng Quan
Cover: Kecheng Quan
Layout: Kecheng Quan
Printed by xxxxxxxx
ISBN (printed version): xxxxxxx
Magnetic Nanoparticles for the Control of Infectious Biofilms
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Wednesday 9 June, 2021 at 11:00 hours
by
Kecheng Quan
born on 23 August 1989
in Hebei, China
Supervisors
Prof. H. J. Busscher
Prof. H. C. van der Mei
Prof. Y. Ren
Prof. Z. Zhang
Assessment committee
Prof.
A. W. Friedrich
Prof. L. Shi
Prof. W. J. Quax
Paranimfen:
Ke Ren
Table of Contents
Chapter 1 General Introduction and Aim of this ThesisChapter 1.1 Possibilities and Impossibilities of Magnetic Nanoparticle Use in the Control of Infectious Biofilms
(Journal of Materials Science & Technology 2021, 69: 69-78. IF: 6.155) Chapter 1.2 Water in Bacterial Biofilms
(Submitted)
Chapter 1.3 Aim of the thesis
1
Chapter 2 Homogeneous Distribution of Magnetic, Antimicrobial-Carrying Nanoparticles
through an Infectious Biofilm Enhances Biofilm-Killing Efficacy (ACS Biomaterials Science and Engineering 2020, 6: 205-212. IF: 4.152)
57
Chapter 3 Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles
Enhanced Bacterial Killing by Antibiotics (Small 2019, 15: 1902313. IF: 11.459)
81
Chapter 4 Influence of Interaction between Surface-Modified Magnetic Nanoparticles
with Infectious Biofilm Components in Artificial Channel Digging and Biofilm Eradication by Antibiotics In vitro and In vivo
(Nanoscale 2021, 13: 4644-4653. IF: 6.895)
101
Chapter 5 On-demand Pull-off of Magnetic Nanoparticles from Biomaterial Surfaces to
Create Channels in Implant-Associated Infectious Biofilms for Enhanced Antibiotic Killing Efficacy
(Submitted)
127
Chapter 6 General Discussion 149
Summary Samenvatting 总结
153
