University of Groningen
Magnetic Nanoparticles for the Control of Infectious Biofilms Quan, Kecheng
DOI:
10.33612/diss.170829667
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Publication date: 2021
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Quan, K. (2021). Magnetic Nanoparticles for the Control of Infectious Biofilms. University of Groningen. https://doi.org/10.33612/diss.170829667
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Appendices
Acknowledgements
List of Publications
Acknowledgements
Till this moment do I realise how time flies but I still cannot accept the truth that the final of my PhD is coming. During the past four years, as an “2+2 sandwich” student, I’ve been forth and back between Groningen and Suzhou for several times. Each time for me was a new and challenging start. I have to thank this tough but unforgettable experience for pushing me to be stronger and giving me the chane to meet everyone.
Dear Henk, thank you for giving me the chance to join this program and I really appreciate for what you have done to help me finish my thesis. I first saw you in Suzhou in November 2016 and I heard you singing a Chinese song, which shocked me deeply: how could a foreign professor learn Chinese so well! I like the barbeque you served in your house the first time I went to Groningen and I am proud of being a member of your Chinese running team. I miss the Lamb-and-Beer thing in Suzhou so much and look forward doing it again, and again. As a professor, supervisor, mentor, friend and elder, you taught me more than academic skills, but also how to enjoy being a PhD-candidate, how to enjoy work and how to enjoy life. My PhD project did not work smoothly in the beginning. It was alomst going to fail. But neither of us gave up. We fought together. I still remember the moment that the channels digging idea came out during our discussion in the end of 2018 in Suzhou. Not only it was a turning point of my PhD, but also it made me understand success always comes from desperate and seems-to-be-hopeless struggles. My PhD work is ending. But my academic career is starting! Thank you.
Dear Henny, thank you for your patience and kindness. As my supervisor and mentor, you’ve always been warmhearted and nice to me from the first day I went to Groningen in September 2017. You helped me so many detailed things on both work and life. I can never make them without you. I miss the time with you in Suzhou and Groningen, especially when we were discussing my work and papers. You were so patient to listen and talk to me. I also admire that you have a pair of “magic” eyes that can find any tiny mistakes in writing. Your zero-tolerant spirit in science deeply touched and encouraged me. It is a capability and also attitude that I have to learn in the rest of my academic life.
Dear Yijin, thank you for being my co-supervisor and all of the efforts you have done to help me finish my thesis and papers. As a Chinese, you helped me a lot in Groningen especially the first time I went there. Also thank you for your nice suggestions to help me apply for a job.
Dear Brandon, thank you for teaching and guiding me microbiological experiments and also all of the efforts you have done to help me finish my thesis and papers. I still remember the first time I talked with you about my work plan in the first day I went to BME. I was so stressful to speak to a foreigner an d a native English speaker for such a long time because my English was so poor. But you were very nice and you could understand what I was talking about , which was amazing for me. In the rest of time in Groningen, I often went to your office for help and the door was always open for me. Each time before the month meeting
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with other supervisors, I would talk with you first and then you could help me for the language problems during the meeting. You are really a rock for me to help me survive from the beginnings in Groningen. Thank you.
Dear Zexin, you joined my program and became my Chinese supervisor in the lowest point of my PhD period. Ever since you appeared, things became better and better. You helped me communicate with my Dutch supervisors and with your help, communication became clearer and misunderstandings were eliminated gradually. Then my work moved forward more and more smoothly. As a “2+2” student, things in Soochow university were not easy for me and I met a lot of troubles especially after the outbreak of the pandemic. Without your help and support, I can never finish my work so fast. Thank you. I feel so lucky to meet you in Suzhou, not only as a supervisor, but also as a friend.
Dear Hong, thank you for giving me the chance to join this program. Thank you for your help during my lowest point. Thank you for providing me a free and pure environmen to do academic work. Most of my PhD work was done in MacBio and I really appreciate to join such a perfect group.
Dear Prof. A. W. Friedrich, Prof. L. Shi and Prof. W. J. Quax, thank you for being the reading committee members of my thesis and spending your precious time on evaluating my thesis.
I would like to thank all the help and support from BME staff: Wya, thank you for helping me about the immigration procedures, the visa application and other financial problems.Theo, thank you for the confocal training. Ed, thank you for helping me on computer things and problems of my electronic accounts in UMCG. Ina, thank you for helping me on so many daily problems. Willem, thank you for helping and reminding me when I was doing experiments in laboratories. Betsy, thank you for helping me order chemical reagents. Gesinda, thank you for the OCT training. Hans, thank you for the DLS training. Reinier, Marja, Willy, thank you for your helps during daily work.
Dear BME colleagues and fellows, it is my honor to meet you. I really enjoyed and miss those happy time with you. With your company and help, I did not feel scared and boring in a foreign country. Bingran and Feifei, you helped me the accommodation things, you taught me how to cook and you also let me know how to live in Groningen in the first time I arrived. I really appreciate your big help, thank you. Yafei, thank you for helping me find accommodation in the first time I went to Groningen. Thank you for picking me up in train station the first moment I arrived in Groningen. Thank you for introducing me to everyone the first day I went to BME. Thank you for taking me to apply for the bank card and telephone card. Yong, thank you for your help on work and life in Groningen. You are an academic idol in my heart and I always feel so lucky to meet you. Yiyang, thank you for doing such a big favor to me about my bank card problem and house moving problem. Ke Ren and Huaiying, thank you for being my paranymphs and also for your company. Since I will finish my defence online and not come back to Groningen, there will be a lot of things that I have to trouble you. I feel sorry about that and I really appreciate your help. I also enjoyed the time we played together.
Xiaoxiang, I am happy to share my feelings with you during the past several years especially about our boss and work. Thank you for your help on experiments and your guidance on job application. Playing Wolf Killing and Texas Poker with you was also full of fun. Lu Yuan, thank you for your help on thesis things and your guidance on postdoctoral application. I also enjoyed the time playing games and doing all kinds of sports with you. Qihui, it was nice to talk with you about academic problems and thank you for your suggestions. JP and Fangjie, I really miss and enjoyed the experience of our Germany and French skiing. Hongping and Xinhong, Guangyue and Jingjin, Zhiwei, Linyan, Yanyan, Chengxiong, Yingruo, Liangliang, Lu Ge, Ruifang, Yuanfeng, Can Wang, Yuchen, Hao Wei, Zhenya, Kaiqi, Damla, Abby, Mari, Yori, Colin, Vera, Valentina, thank you for your help and really miss you all.
I would also like to thank the people I met in Suzhou: Qian Yu, it was nice to talk and play basketball with you. I first knew you because of your name (sorry) in Suzhou Polymer Annual meeting in 2015. However, after 4 years, when it comes to “yuqian”, you are the first one I am thinking of. Dan Li and Lei Wang, thank you for your help in the beginning of my PhD. Qing Zheng, thank you for everything you have done for me. I cannot list how many things you have helped me but without your help, I could never finish my work in Suzhou so quickly. I also appreciate the conversations we had. Thank you. Liyin, thank you for your company during the past 3 years. We witnessed each other’s depression, failure, happiness, success and growth. It is lucky to meet you in Suzhou. Rui Chen, Zengchao, Limin, Jinbo, Wenjun, Ting Wei, Qi Liu, Yangcui, Lijuan, Ruyan, Yan Luo, Changming, Peixi, Ya Sun, Zhiqiang, Yaran, Huaguang, Sinan, Miaomiao, Xiaoliang, Wenqing, Pen Liu, thank you for your help and company. About other “2+2” fellows, Guimei, Renfei, Sidi, Rui Shi, Tianrong, Cong Li, Qiaolan, thank you for your kind help in Suzhou. Linzhu, Guang Yang, Dayuan, Shuang Tian, it is nice to know you although we have seldom seen each other due to this special programe. Wish you all finish your thesis smoothly!
Finally, I would like to show my great thankfulness and apology to my parents, family members and friends. Without your help and support, I cannot insist and finish my PhD. 感谢我的父母、各位亲人和朋友，是你们的支持、帮 助和努力，让我明白我不是一个人孤军奋战，除了自身的荣耀得失，我身上 也肩负着你们的期许和关怀。熬过了一段段漫长的艰苦岁月，让我深刻的体 会到什么是越努力越幸运的感觉。谢谢你们。尽管未来的路依旧迷雾重重， 充满挑战，但心中似乎多了几分从容。 Kecheng May 2021 in Baoding
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List of Publications
In Groningen• K. Quan, G. Jiang, J. Liu, Z. Zhang*, Y. Ren, H. J. Busscher*, H. C. van der Mei, B. W. Peterson*, Influence of interaction between surface-modified magnetic nanoparticles with infectious biofilm components in artificial channel digging and biofilm eradication by antibiotics in vitro and in vivo. Nanoscale 2021, 13: 4644-4653. (IF:6.895)
• K. Quan,Z. Zhang*, Y. Ren, H. J. Busscher*, H. C. van der Mei*, B. W. Peterson,Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms. Journal
of Materials Science & Technology 2021, 69: 69-78. (IF:6.155)
• K. Quan, Z. Zhang*, Y. Ren, H. J. Busscher*, H. C. van der Mei, B. W. Peterson*, Homogeneous distribution of magnetic, antimicrobial-carrying nanoparticles through an infectious biofilm enhances biofilm-killing efficacy. ACS Biomaterials Science & Engineering 2020, 6: 205-212. (IF:4.389)
• K. Quan,Z. Zhang*, H. Chen, X. Ren, Y. Ren, B. W. Peterson, H. C. van der Mei*, H. J. Busscher*, Artificial channels in an infectious biofilm created by magnetic nanoparticles enhanced bacterial killing by Antibiotics. Small 2019, 1902313. (IF:11.459)
• K. Quan, Z. Zhang*, Y. Ren, H. J. Busscher*, H. C. van der Mei*, B. W. Peterson, On-demand pull-off of magnetic nanoparticles from biomaterial surfaces to create channels in implant-associated infectious biofilms for enhanced antibiotic killing efficacy. Under review in
Materials Science & Engineering C. (IF:5.880)
• K. Quan1, J. Hou1, Z. Zhang, Y. Ren, B. W. Peterson, H.-C. Flemming, C. Mayer, H. J. Busscher, H. C. van der Mei*,Water in bacterial biofilms and the origin of a rudimentary vascular system in biofilm matrices. Under review in Critical Reviews in Microbiology. (IF:7.349)
Before Groningen
• K. Quan1, G. Li1, L. Tao, Q. Xie, Q. Yuan, X. Wang*, Diaminopropionic acid reinforced graphene sponge and its use for hemostasis. ACS Applied Materials & Interfaces 2016, 8: 7666-7673. (IF:8.758)
• K. Quan1, G. Li1, D. Luan, Q. Yuan, L. Tao, X. Wang*, Black hemostatic sponge based on facile prepared cross-linked Graphene. Colloids Surfaces B: Biointerfaces 2015, 132: 27-33. (IF:4.389)
• G. L, K. Quan, C. Xu, B. Deng, X. Wang*, Synergy in thrombin-graphene sponge for improved hemostatic efficacy and facile utilization. Colloids Surfaces B: Biointerfaces 2018, 161: 27-34. (IF:4.389)
• G. Li, K. Quan, Y. Liang, T. Li, Q. Yuan, L. Tao, Q. Xie, X. Wang*, Graphene-montmorillonite composite sponge for safe and effective hemostasis. ACS Applied Materials & Interfaces 2016, 8: 35071-35080. (IF:8.758)
• G. Li, H. Zhao, J. Hong, K. Quan, Q. Yuan, X. Wang*, Antifungal graphene oxide-borneol composite. Colloids Surfaces B: Biointerfaces 2017, 160: 220-227. (IF:4.389)
• G. Li, X. Wang*, L. Tao, Y. Li, K. Quan, Y. Wei, L. Chi, Q. Yuan*, Cross-linked graphene membrane for high-performance organics separation of emulsions. Journal of Membrane
