University of Groningen
Adaptive antimicrobial nanocarriers for the control of infectious biofilms
Liu, Yong
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Publication date: 2019
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Liu, Y. (2019). Adaptive antimicrobial nanocarriers for the control of infectious biofilms. University of Groningen.
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Adaptive Antimicrobial
Nanocarriers for the
Control of Infectious Biofilms
Adaptive Antimicrobial Nanocarriers for the Control of Infectious Biofilms
By Yong Liu
University Medical Center Groningen, University of Groningen
Groningen, The Netherlands
Copyright © 2019 by Yong Liu
Cover designed by Yong Liu
Printed by IPSKAMP printing
ISBN (printed version) 978-94-034-1607-6
ISBN (electronic version) 978-94-034-1606-9
Adaptive Antimicrobial
Nanocarriers for the Control of
Infectious Biofilms
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Monday 27 May 2019, at 12.45 hours
by
Yong Liu
born on 17 June 1987
in Sichuan, China
Supervisors
Prof. H.J. Busscher
Prof. H.C. van der Mei
Prof. Y. Ren
Prof. Linqi Shi
Assessment Committee
Prof. W.J. Quax
Prof. P.H. Elsinga
Prof. H. Chen
Paranimfen: Damla Keskin Lu Yuan
Chapter 1 Introduction
Nanotechnology‐Based Antimicrobials and Delivery Systems for Biofilm‐ Infection Control
(Chem. Soc. Rev. 2019, 48, 428–446. IF: 40.182)
1
General Aim of This Thesis 23
Chapter 2 Surface-Adaptive, Antimicrobially Loaded, Micellar Nanocarriers with Enhanced Penetration and Killing Efficiency in Staphylococcal Biofilms (ACS Nano 2016, 10, 4779−4789. IF: 13.709)
27
Chapter 3 Eradication of Multidrug-Resistant Staphylococcal Infections by Light-Activatable Micellar Nanocarriers in a Murine Model
(Adv. Funct. Mater. 2017, 27, 1701974. IF: 13.325)
47
Chapter 4 Nanocarriers with Conjugated Antimicrobials to Eradicate Pathogenic Biofilms Evaluated in Murine In Vivo and Human Ex Vivo Infection Models
(Acta Biomater. 2018, 79, 331–343. IF: 6.383)
71
Chapter 5 Dual-antimicrobial Conjugates in Leukocyte-like Nanocarriers to Eradicate Intra-macrophageal Staphylococci (to be submitted)
103
Chapter 6 General discussion: Perspectives on and Need to Develop New Infection Control Strategies (submitted for publication in: Advances in antimicrobial and osteoinductive studies, Bingyun Li, Thomas Fintan Moriarty, Thomas Webster, Malcolm Xing (eds.), Springer International Publishing AG)
131
Summary 143
Samenvatting 147
Acknowledgements 153
