Fc γ receptors and the complement system in T cell activation
Jong, J.M.H. de
Citation
Jong, J. M. H. de. (2007, December 13). Fc γ receptors and the complement system in T cell activation. Retrieved from https://hdl.handle.net/1887/12491
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12491
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FcγReceptors and the complement
system in T cell activation.
Judith M.H. de Jong
FcγReceptors and the complement system in
T cell activation.
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 13 december 2007 klokke 13.45 uur
door
Judith Maria Hendrika de Jong geboren te Breda in 1977
Promotiecommissie:
Promotor: Prof. Dr. T.W.J. Huizinga Co-promotoren: Dr. R.E.M. Toes
Dr. J.S. Verbeek
Referent: Dr. T.R.D.J. Radstake Universitair Medisch Centrum Nijmegen Overige leden: Prof. Dr. M.R. Daha
Prof. Dr. P.S. Hiemstra
The research presented in this thesis was performed at the department of Rheumatology of the Leiden University Medical Center, The Netherlands, and was supported by a grant of the Dutch Organization for Scientific Research.
Financial support for the publication of this thesis was provided by the J.E. Jurriaanse Stichting, the Dutch Arthritis Foundation and Sticares InterACT BV.
Used by permission: Chapter 3 - ©2007 The American Association of Immunologists, Inc.
ISBN: 90-9022169-4
Cover: Dennis Blaak, Vormtaal Druk: Ponsen & Looijen
Voor mama
Contents
Chapter 1 General Introduction 9
Chapter 2 Dendritic cells, but not macrophages or B cells, activate 27 MHC class II-restricted CD4+ T cells upon immune-
complex uptake in vivo.
Immunology 2006; 119:499-506
Chapter 3 A novel role of complement factor C1q in augmenting 37 the presentation of antigen captured in immune complexes
to CD8+ T lymphocytes.
J. Immunol. 2007; 178:7581-7586
Chapter 4 Murine Fc Receptors for IgG are redundant in facilitating 45 presentation of immune complex derived antigen to CD8+
T cells in vivo.
Mol. Immunol. 2006; 43:2045-2050
Chapter 5 Single Nucleotide Polymorphisms (SNPs) in the C5 gene 53 associate with susceptibility to RA.
Chapter 6 Summary and discussion 69
Nederlandse samenvatting 77
Nawoord 86
Curriculum Vitae 88
