Cover Page
The handle http://hdl.handle.net/1887/19038 holds various files of this Leiden University dissertation.
Author: Horst, Eelke van der
Title: Drugs, structures, fragments : substructure-based approaches to GPCR drug discovery and design
Date: 2012-05-31
Drugs, Structures, Fragments
Substructure-based approaches to GPCR drug discovery and design
Drugs, Structures, Fragments
Substructure-based approaches to GPCR drug discovery and design
P ROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 31 mei 2012
klokke 16:15 uur
door
Eelke van der Horst
geboren te Voorburg in 1976
Promotiecommissie
Promotor: Prof. Dr. A. P. IJzerman Copromotor: Dr. A. Bender
Overige leden: Prof. Dr. H. van Vlijmen Prof. Dr. T. Hankemeier Prof. Dr. J. de Vlieg Prof. Dr. M. Danhof
.
Cidrux Pharminformatics B.V. is gratefully acknowledged for financially supporting the printing of this thesis.
The research described in this thesis was performed at the Division of Medicinal Chemistry of the Leiden/Amsterdam Center for Drug Research, Leiden University (Leiden, The Netherlands). This research was conducted as part of the GPCR forum of the Dutch Top Institute Pharma (project number D1-105).
This thesis was printed by Wöhrmann Print Service (Zutphen, The Netherlands)
千里之行, 始于足下 Qiān lĭ zhī xíng, shĭ yú zú xià (The journey of a thousand miles begins with a single step)
Lao-tzu, The Way of Lao-tzu Chinese philosopher (604 BC - 531 BC)
Contents
7