University of Groningen
Challenges and opportunities in quantitative brain PET imaging
Lopes Alves, Isadora
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Publication date: 2017
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Lopes Alves, I. (2017). Challenges and opportunities in quantitative brain PET imaging. University of Groningen.
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Challenges and opportunities in
quantitative
brain PET imaging
The research reported in this thesis was carried out within the Department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen.
The reported research contained in this thesis was financially supported by a scholarship from the Graduate School of Medical Sciences (Abel Tasman Talent Program) of the University Medical Center Groningen.
The printing of this thesis was financially supported by the University Medical Center Groningen and the research school of Behavioral and Cognitive Neurosciences (BCN).
Cover design: Isadora Lopes Alves and colleagues Printed by: Ridderprint
ISBN: 978-90-367-9820-4 (Hard copy)
ISBN: 978-90-367-9819-8 (Electronic version)
Dissertation of University of Groningen, Groningen, the Netherlands Copyright © 2017 Isadora Lopes Alves
Challenges and opportunities
in quantitative brain PET imaging
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Wednesday 7 June 2017 at 16.15 hours
by
Isadora Lopes Alves
born on 9 of April of 1990 in Pelotas, Rio Grande do Sul, BrazilSupervisors
Prof. R. Boellaard
Prof. A.M. Marques da Silva
Co-supervisors
Dr. A.T.M. Willemsen Dr. M. Koole
Assessment Committee
Prof. A. Lammertsma Prof. T. van Laar Prof. M. Lubberink
Paranymphs
Dr. D. Vállez García
CONTENTS
IntroductionChapter 1 General Introduction 9
Section I: Dual time point quantification Chapter 2 Dual time point method for the quantification of irreversible tracer kinetics: a reference tissue approach applied to [18F]-FDOPA brain PET 25
Chapter 3 Dual time point imaging for post-dose binding potential estimation applied to a [11C]raclopride PET dose occupancy study 49
Section II: Back-translation of quantitative methods: from clinical to preclinical studies Chapter 4 Contribution of neuroinflammation to changes in [11C]flumazenil binding in the rat brain: evaluation of the inflamed pons as reference tissue 75
Chapter 5 Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain 93
Chapter 6 Parametric imaging of [11C]flumazenil binding in the rat brain 117
Overview and discussion Chapter 7 Summary 139
Chapter 8 Concluding Remarks and Future Perspectives 149
Chapter 9 Nederlandse Samenvatting 163
