University of Groningen
The consequences of environmental conditions for antagonistic pleiotropic effects of cellular
senescence
van Vliet, Thijmen
DOI:
10.33612/diss.156836397
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Vliet, T. (2021). The consequences of environmental conditions for antagonistic pleiotropic effects of
cellular senescence. University of Groningen. https://doi.org/10.33612/diss.156836397
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
554157-L-bw-Vliet 554157-L-bw-Vliet 554157-L-bw-Vliet 554157-L-bw-Vliet Processed on: 13-1-2021 Processed on: 13-1-2021 Processed on: 13-1-2021
Processed on: 13-1-2021 PDF page: 146PDF page: 146PDF page: 146PDF page: 146 146
Curriculum Vitae Thijmen van Vliet Education:
• Doctor of Philosophy (September 2016 – September 2020)
ERIBA, University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands. Supervisor: Dr. Marco Demaria
Thesis title: The consequences of environmental conditions for antagonistic pleiotropic effects of cellular senescence.
• Master of Science Cum Laude (September 2014 – June 2016)
Top master program Medical and Pharmaceutical Drug innovation (MPDI), University of Groningen, Groningen, The Netherlands.
• Bachelor of Science (September 2011- June 2014)
Biology, Major: Biomedical sciences, University of Groningen, Groningen, The Netherlands. Professional grants and awards
• Graduate school of Medical Sciences (GSMS) PhD Scholarship (June 2016; 4 years salary and bench fee)
• Simons fonds travel award (March 2017, 800 EUR)
• Jan Kornelis De Cock-Stichting Research Grant (Feb 2018; 4000 EUR)
• 10th Alliance for Healthy Aging Research travel award, New Castle University and Mayo clinic
Rochester (Oct 2018, travel expenses)
147 List of Publications
1. van Vliet, T., Kohli, J., Demaria, M., Consequences of senotherapies for tissue repair and reprogramming, Translational Medicine of Aging 3, 31-36 (2019)
2. van VlietT., Franzin, R., Seelen, M., Demaria, M., Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression,
manuscript in revision.
3. van Vliet, T., Casciaro, F., Demaria, M., To breathe or not to breathe: understanding how oxygen modulation regulates aging, manuscript in revision.
4. Fontana, L., Mitchell, S.E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D.S., Maissin, P., Speakman, J.R., Demaria, M., The effects of graded caloric restriction: XII Comparison of mouse to human impact on cellular senescence in the colon, Aging Cell 17,
e12746 (2018).
5. Wang, B., Brandenburg, S., Hernandez-Segura, A., van Vliet, T., Jongbloed, E., Wilting, S., Ohtani, N., Jager, A., Demaria, M, CDK4/6 inhibition promotes senescent status with restricted secretory phenotype and reduced toxicity. Biorxiv 2020.06.05.135715 (2020). dio:10.1101/2020.06.05.135715.
6. Peng, X., Wu, Y., Brouwer, U., van Vliet, T., Wang, B., Demaria, M., Barazzuol, L., Coppes, R.P., Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/ progenitor cell niche, Cell Death and Disease 11, 1-11 (2020)
554157-L-bw-Vliet 554157-L-bw-Vliet 554157-L-bw-Vliet 554157-L-bw-Vliet Processed on: 13-1-2021 Processed on: 13-1-2021 Processed on: 13-1-2021
Processed on: 13-1-2021 PDF page: 147PDF page: 147PDF page: 147PDF page: 147 146
Curriculum Vitae Thijmen van Vliet Education:
• Doctor of Philosophy (September 2016 – September 2020)
ERIBA, University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands. Supervisor: Dr. Marco Demaria
Thesis title: The consequences of environmental conditions for antagonistic pleiotropic effects of cellular senescence.
• Master of Science Cum Laude (September 2014 – June 2016)
Top master program Medical and Pharmaceutical Drug innovation (MPDI), University of Groningen, Groningen, The Netherlands.
• Bachelor of Science (September 2011- June 2014)
Biology, Major: Biomedical sciences, University of Groningen, Groningen, The Netherlands. Professional grants and awards
• Graduate school of Medical Sciences (GSMS) PhD Scholarship (June 2016; 4 years salary and bench fee)
• Simons fonds travel award (March 2017, 800 EUR)
• Jan Kornelis De Cock-Stichting Research Grant (Feb 2018; 4000 EUR)
• 10th Alliance for Healthy Aging Research travel award, New Castle University and Mayo clinic
Rochester (Oct 2018, travel expenses)
147 List of Publications
1. van Vliet, T., Kohli, J., Demaria, M., Consequences of senotherapies for tissue repair and reprogramming, Translational Medicine of Aging 3, 31-36 (2019)
2. van VlietT., Franzin, R., Seelen, M., Demaria, M., Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression,
manuscript in revision.
3. van Vliet, T., Casciaro, F., Demaria, M., To breathe or not to breathe: understanding how oxygen modulation regulates aging, manuscript in revision.
4. Fontana, L., Mitchell, S.E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D.S., Maissin, P., Speakman, J.R., Demaria, M., The effects of graded caloric restriction: XII Comparison of mouse to human impact on cellular senescence in the colon, Aging Cell 17,
e12746 (2018).
5. Wang, B., Brandenburg, S., Hernandez-Segura, A., van Vliet, T., Jongbloed, E., Wilting, S., Ohtani, N., Jager, A., Demaria, M, CDK4/6 inhibition promotes senescent status with restricted secretory phenotype and reduced toxicity. Biorxiv 2020.06.05.135715 (2020). dio:10.1101/2020.06.05.135715.
6. Peng, X., Wu, Y., Brouwer, U., van Vliet, T., Wang, B., Demaria, M., Barazzuol, L., Coppes, R.P., Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/ progenitor cell niche, Cell Death and Disease 11, 1-11 (2020)
