University of Groningen
The consequences of environmental conditions for antagonistic pleiotropic effects of cellular
senescence
van Vliet, Thijmen
DOI:
10.33612/diss.156836397
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Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Vliet, T. (2021). The consequences of environmental conditions for antagonistic pleiotropic effects of
cellular senescence. University of Groningen. https://doi.org/10.33612/diss.156836397
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1
The consequences of environmental
conditions for antagonistic
pleiotropic effects of cellular
senescence
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Tuesday 16 February 2021 at 9:00 hours
by
Thijmen Johannes van Vliet
born on 26 March 1992 in Roden
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Processed on: 13-1-2021 PDF page: 2PDF page: 2PDF page: 2PDF page: 2
2
Supervisor
Prof. M.A.T.M. van Vugt
Co-supervisor
Dr. M. DemariaAssessment Committee
Prof. R.P. Coppes Prof. J.W. Jonker Prof. J. Gil 3Table of Contents
Chapter 1: General Introduction……….……..5
Chapter 2: Consequences of senotherapies for tissue repair and reprogramming………11
Chapter 3: The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon………..…27
Chapter 4: Caloric restriction delays cutaneous wound healing via impairment of cellular senescence ………35
Chapter 5: Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression………51
Chapter 6: To breathe or not to breathe: understanding how oxygen modulation regulates ageing………83
Chapter 7: General discussion………..….127
Dutch Summary………139
Acknowledgements……….…….143
Curriculum Vitae……….…146
554157-L-bw-Vliet 554157-L-bw-Vliet 554157-L-bw-Vliet 554157-L-bw-Vliet Processed on: 13-1-2021 Processed on: 13-1-2021 Processed on: 13-1-2021
Processed on: 13-1-2021 PDF page: 3PDF page: 3PDF page: 3PDF page: 3
2
Supervisor
Prof. M.A.T.M. van Vugt
Co-supervisor
Dr. M. DemariaAssessment Committee
Prof. R.P. Coppes Prof. J.W. Jonker Prof. J. Gil 3Table of Contents
Chapter 1: General Introduction……….……..5
Chapter 2: Consequences of senotherapies for tissue repair and reprogramming………11
Chapter 3: The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon………..…27
Chapter 4: Caloric restriction delays cutaneous wound healing via impairment of cellular senescence ………35
Chapter 5: Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression………51
Chapter 6: To breathe or not to breathe: understanding how oxygen modulation regulates ageing………83
Chapter 7: General discussion………..….127
Dutch Summary………139
Acknowledgements……….…….143
Curriculum Vitae……….…146
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4 5
Chapter 1
General Introduction
Thijmen van Vliet.
European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), 9713AV Groningen, The Netherlands
