University of Groningen
Birth and death of cellular senescence Wang, Boshi
DOI:
10.33612/diss.131223530
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
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Wang, B. (2020). Birth and death of cellular senescence. University of Groningen. https://doi.org/10.33612/diss.131223530
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Birth and death of cellular
senescence
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Wednesday 9 September 2020 at 9.00 hours
by
Boshi Wang
born on 12 November 1988 in Jilin, China
Supervisor
Prof. C.F. CalkhovenCo-supervisor
Prof. M. DemariaAssessment Committee
Prof. R. Bernards Prof. M. van Vugt Prof. M. NaritaTable of Contents
Chapter 1: General Introduction --- 1
Chapter 2: Senescent cells in cancer therapy: friends or foes? --- 5
Chapter 3: CDK4/6 inhibition promotes senescent states with restricted secretory phenotype and reduced toxicity --- 39
Chapter 4: Elimination of age-related senescent cells improve healthspan and tissue homeostasis --- 85
Chapter 5: An investigation of contributing factors to natural immune clearance of senescent cells --- 99
Chapter 6: General summary and discussion --- 117
Dutch Summary --- 127
Acknowledgements --- 131
Cover design: Ipskamp Printing Printing: Ipskamp Printing ISBN/EAN: 978-94-028-2123-9
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