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VU Research Portal

Towards clinical implementation of personalised PRRT in patients with

neuroendocrine tumours

Huizing, D.M.V.

2021

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Huizing, D. M. V. (2021). Towards clinical implementation of personalised PRRT in patients with neuroendocrine

tumours: Optimisation of nuclear imaging techniques, dosimetry and response evaluation.

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Contents

Chapter 1 Introduction and outline 7

Part I - Quantitative nuclear imaging and post-therapy dosimetry in NETs Chapter 2 Multicentre quantitative 68Ga PET/CT performance

harmonisation

23

Chapter 3 177Lutetium SPECT/CT: evaluation of collimator, photopeak

and scatter correction

39

Chapter 4 Dosimetry methods and clinical applications in peptide receptor radionuclide therapy for neuroendocrine tumours: a literature review

53

Chapter 5 A head-to-head comparison between two commercial software packages for hybrid dosimetry after peptide receptor radionuclide therapy

83

Part II - Clinical outcome after PRRT

Chapter 6 Parameters to predict progression free and overall survival after peptide receptor radionuclide therapy: a multivariate analysis in 782 patients

113

Chapter 7 Haematotoxicity during PRRT: baseline parameters differences and effect on patient’s management

139

Chapter 8 Early response assessment and prediction of overall survival after peptide receptor radionuclide therapy

157

Chapter 9 Discussion and future perspectives 183

Appendices Summary Samenvatting Affiliations List of publications Dankwoord Curriculum vitae 197 203 211 217 221 229

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De ambitie is dat door middel van dit onderzoek posttherapie dosimetrie en responsevaluatie na PRRT wordt geoptimaliseerd, om zo uiteindelijk te kunnen zorgen voor

The aim of this thesis was to quantify and harmonise nuclear imaging techniques for patients with neuroendocrine tumours (NETs), and to identify parameters associated with