University of Groningen
Towards personalised treatment of patients with colorectal liver metastases Hof, Joost
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2019
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Hof, J. (2019). Towards personalised treatment of patients with colorectal liver metastases. Rijksuniversiteit Groningen.
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towards personalised treatment of patients with
colorectal liver metastases
JOOST HOF
Colofon
J. Hof
Towards personalised treatment of patients with colorectal liver metastases
ISBN online version 978-94-034-1319-8 ISBN printed version 978-94-034-1320-4
Layout and design by Matthijs Ariens, persoonlijkproefschrift.nl.
Printed by Ipskamp Printing, proefschriften.net.
This thesis was financially supported by the University Medical Center Groningen, Graduate School of Medical Sciences (University of Groningen), Junior Scientific Masterclass (University of Groningen), DEMCON advanced mechatronics, Pfizer B.V., Angiocare B.V.
and Bayer B.V.
Copyright © 2019 J. Hof
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.
Towards personalised treatment of patients with
colorectal liver metastases
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 27 februari 2019 om 14.30 uur
door
Joost Hof
geboren op 8 december 1990 te Emmen
Promotores
Prof. dr. R.H. Sijmons Dr. K.P. de Jong
Copromotor Dr. K. Kok
Beoordelingscommissie Prof. dr. R.J. Porte
Prof. dr. J.H.M. van den Berg Prof. dr. J. Morreau
Paranimfen J. Osinga R. Modderman
Table of contents
Chapter 1 Introduction and outline of this thesis 9
Part I Association of biomarkers in resected colorectal liver metastases with patient survival
21
Chapter 2 Systematic review of the prognostic role of the immune system after surgery of colorectal liver metastases
Submitted manuscript
23
Chapter 3 B cell expression as prognostic biomarker after surgery for colorectal liver metastases
Submitted manuscript
49
Chapter 4 Low tumour expression of miR-19b and miR-196b predicts a good survival after surgery for colorectal liver metastases
Submitted manuscript
85
Chapter 5 Loss of chromosome 22 predicts a poor survival after surgery for colorectal liver metastases
Manuscript in preparation
101
Part II The role of thermal ablation in the management of patients with colorectal liver metastases
117
Chapter 6 Outcomes after resection and/or radiofrequency ablation for recurrences after treatment of colorectal liver metastases Br J Surg. 2016 Jul;103(8):1055-62.
119
Chapter 7 Radiofrequency ablation is beneficial in simultaneous treatment of synchronous liver metastases and primary colorectal cancer PLoS One. 2018 Mar 15;13(3):e0193385.
139
Part III Overview and future 163
Chapter 8 Summary, discussion and future perspectives 165 Appendix Nederlandse samenvatting
Dankwoord Curriculum vitae
186 190 193
