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University of Groningen Albuminuria: more than a renal risk marker? van den Belt, Sophie Mariëlle

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University of Groningen

Albuminuria: more than a renal risk marker?

van den Belt, Sophie Mariëlle

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

van den Belt, S. M. (2018). Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

Processed on: 17-4-2018 PDF page: 101PDF page: 101PDF page: 101PDF page: 101

Summary and future perspectives

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

Processed on: 17-4-2018 PDF page: 102PDF page: 102PDF page: 102PDF page: 102

102 Chapter 7

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

Processed on: 17-4-2018 PDF page: 103PDF page: 103PDF page: 103PDF page: 103

103 ĚŝƐĞĂƐĞŝŶůĂƚĞƌůŝĨĞ͕ďƵƚƌĞƉƌĞƐĞŶƚĂŶŝŶďŽƌŶĐŚĂƌĂĐƚĞƌŝƐƟĐ͕ƉŽƐƐŝďůLJĚĞƚĞƌŵŝŶŝŶŐĨĂƚĞŽĨ ƚŚĞŝŶĚŝǀŝĚƵĂůŝŶůĂƚĞƌůŝĨĞ͘DŽƌĞƌĞƐĞĂƌĐŚŶĞĞĚƐƚŽďĞĚŽŶĞƚŽĚĞƚĞƌŵŝŶĞƚŚĞĐĂƵƐĞ;ƐͿŽĨ ŝŶĐƌĞĂƐĞĚĂůďƵŵŝŶƵƌŝĂĂƚĂLJŽƵŶŐĂŐĞ͘ dŚĞĐŽůůĞĐƟŽŶŽĨƵƌŝŶĞŝŶƚŚĞĂďŽǀĞĐŽŚŽƌƚǁĂƐƌĂƚŚĞƌĐƵŵďĞƌƐŽŵĞĂŶĚƉĞƌĨŽƌŵĞĚ ǁŝƚŚƚŚĞƵƐĞŽĨƉĂŶƚLJůŝŶĞƌƐŝŶĚŝĂƉĞƌƐ͘dŽŝŵƉƌŽǀĞƚŚĞƋƵĂůŝƚLJŽĨƚŚĞĐŽůůĞĐƚĞĚĚĂƚĂ ŝŶĨƵƚƵƌĞƐƚƵĚŝĞƐ͕ďĞƩĞƌĐŽůůĞĐƟŽŶƚĞĐŚŶŝƋƵĞƐĂƌĞŶĞĞĚĞĚ͘Chapter 3 compared the

ƉĞƌĨŽƌŵĂŶĐĞŽĨĚŝīĞƌĞŶƚƵƌŝŶĞĐŽůůĞĐƟŽŶŵĞƚŚŽĚƐŝŶLJŽƵŶŐĐŚŝůĚƌĞŶ͕ŝŶŽƌĚĞƌƚŽŝĚĞŶƟĨLJ ƚŚĞŵŽƐƚƌĞůŝĂďůĞ͕ƉƌĂĐƟĐĂůĂŶĚĐŽŵĨŽƌƚĂďůĞŵĞƚŚŽĚ͘dŚĞƉĂŶƚLJůŝŶĞƌŵĞƚŚŽĚ͕ǁŚŝĐŚ ǁĂƐƵƐĞĚŝŶĐŚĂƉƚĞƌϮ͕ǁĂƐƚĞƐƚĞĚĂŐĂŝŶƐƚƚŚĞŶĞǁůLJĚĞǀĞůŽƉĞĚWĞĞ^ƉŽƚŵĞƚŚŽĚ͕ĂŶĚ ĐŽŵƉĂƌĞĚƚŽĂƌĞĨĞƌĞŶĐĞƐĂŵƉůĞ;ƚŚĞ͞ƐƚĂŶĚĂƌĚ͟ŵĞƚŚŽĚͿ͕ǁŚŝĐŚǁĂƐĂŶƵŶƉƌŽĐĞƐƐĞĚ ƵƌŝŶĞƐĂŵƉůĞƐƚŽƌĞĚĂƚϰΣ͘dŚĞƐĞƚŚƌĞĞŵĞƚŚŽĚƐǁĞƌĞĐŽŵƉĂƌĞĚƵƐŝŶŐƚŚĞEĂƟŽŶĂů ŽŵŵŝƩĞĞĨŽƌůŝŶŝĐĂů>ĂďŽƌĂƚŽƌLJ^ƚĂŶĚĂƌĚƐ;E>^ͿŐƵŝĚĞůŝŶĞƐĨŽƌŵĞƚŚŽĚĐŽŵƉĂƌŝƐŽŶ͘ tĞĂƌŝŶŐŽĨƚŚĞĚŝĂƉĞƌĂŶĚƟŵĞĨŽƌƐĞŶĚŝŶŐƚŽƚŚĞůĂďŽƌĂƚŽƌLJǁĞƌĞƐŝŵƵůĂƚĞĚďLJƐƚŽƌŝŶŐ ƚŚĞƉĂŶƚLJůŝŶĞƌƐĂŶĚWĞĞ^ƉŽƚƐĂƚĚŝīĞƌĞŶƚƚĞŵƉĞƌĂƚƵƌĞƐ͕ƚŽĞŶƐƵƌĞƚŚĂƚƚŚĞƌĞƐƵůƚƐ ĂĐĐƵƌĂƚĞůLJƌĞƉƌĞƐĞŶƚƚŚĞŝŶǀŝǀŽƐŝƚƵĂƟŽŶ͘dŚĞƌĞƐƵůƚƐƐŚŽǁƚŚĂƚƚŚĞWĞĞ^ƉŽƚĚĞǀŝĐĞŚĂƐ ĂǀĞƌLJŚŝŐŚĂŶĂůLJƟĐĂůƉĞƌĨŽƌŵĂŶĐĞ͕ǁŝƚŚĂƐŵĂůůďŝĂƐ͕ŚŝŐŚƉƌĞĐŝƐŝŽŶĂŶĚŚŝŐŚĂĐĐƵƌĂĐLJ͘ dŚĞWĞĞ^ƉŽƚƉĞƌĨŽƌŵĞĚŵĂƌŬĞĚůLJďĞƩĞƌŝŶŵĞĂƐƵƌŝŶŐƵƌŝŶĂƌLJĂůďƵŵŝŶĐŽŵƉĂƌĞĚƚŽƚŚĞ ƉĂŶƚLJůŝŶĞƌŵĞƚŚŽĚ͘DŽƌĞŽǀĞƌ͕ƚŚĞWĞĞ^ƉŽƚŚĂĚŽƚŚĞƌĂĚǀĂŶƚĂŐĞƐŽǀĞƌƚŚĞƉĂŶƚLJůŝŶĞƌ ĨŽƌƚŚĞƵƐĞŝŶĐůŝŶŝĐĂůƉƌĂĐƟĐĞ͘/ƚǁĂƐĞĂƐŝĞƌƚŽƉƌŽĐĞƐƐĂƚƚŚĞůĂďŽƌĂƚŽƌLJ͕ŵŽƌĞŚLJŐŝĞŶŝĐ ŝŶƵƐĞĂŶĚŵŽƌĞĐŽŶǀĞŶŝĞŶƚŝŶƵƐĞĨŽƌĐŚŝůĚƌĞŶǁŚŽǁĞƌĞĂůƌĞĂĚLJĐŽŶƟŶĞŶƚĨŽƌƵƌŝŶĞ͘ ůƚŽŐĞƚŚĞƌ͕ƚŚĞWĞĞ^ƉŽƚǁĂƐƐŚŽǁŶƚŽďĞĂǀĞƌLJĂƉƉƌŽƉƌŝĂƚĞƚŽŽůĨŽƌƚŚĞĐŽůůĞĐƟŽŶŽĨ ƵƌŝŶĞĨŽƌĂůďƵŵŝŶƵƌŝĂĂƐƐĞƐƐŵĞŶƚŝŶLJŽƵŶŐĐŚŝůĚƌĞŶ͘ /ŶChapter 4͕ƚŚĞWĞĞ^ƉŽƚǁĂƐƵƐĞĚƚŽĞǀĂůƵĂƚĞĚŝīĞƌĞŶƚĐŽůůĞĐƟŽŶƐƚƌĂƚĞŐŝĞƐĨŽƌ ƉƌŽǀŝĚŝŶŐĂŐƵŝĚĞůŝŶĞŽŶĂůďƵŵŝŶƵƌŝĂŵĞĂƐƵƌĞŵĞŶƚŝŶƚŽĚĚůĞƌƐ͘^ĞǀĞƌĂůƐƚƌĂƚĞŐŝĞƐǁĞƌĞ ƚĞƐƚĞĚĂŶĚĐŽŵƉĂƌĞĚ͗ƐŝŶŐůĞƐĂŵƉůĞƵƌŝŶĞĐŽůůĞĐƟŽŶǀĞƌƐƵƐƌĞƉĞĂƚĞĚƵƌŝŶĞƐĂŵƉůŝŶŐĂŶĚ ĮƌƐƚŵŽƌŶŝŶŐǀŽŝĚƵƌŝŶĞƐĂŵƉůĞǀĞƌƐƵƐƌĂŶĚŽŵĚĂLJƐĂŵƉůĞ͘dŚĞŵŽƐƚŽƉƟŵĂůŵĞƚŚŽĚ ;ǁŝƚŚ ƚŚĞ ůŽǁĞƐƚ ŝŶƚƌĂͲŝŶĚŝǀŝĚƵĂů ǀĂƌŝĂďŝůŝƚLJ ŽĨ ĂůďƵŵŝŶƵƌŝĂͿ ǁĂƐ ƚŚƌĞĞ ĐŽŶƐĞĐƵƟǀĞ ĐŽůůĞĐƟŽŶƐŽĨĮƌƐƚŵŽƌŶŝŶŐǀŽŝĚƵƌŝŶĞƐĂŵƉůĞƐ͕ƌĞƉĞĂƚĞĚŽǀĞƌƟŵĞ͘dŚŝƐŝƐŝŶůŝŶĞǁŝƚŚ ĞĂƌůŝĞƌĮŶĚŝŶŐƐŝŶĂĚƵůƚƐ͘/ŶƚĞƌĞƐƟŶŐůLJ͕ƚŚĞƵƐĞŽĨĂůďƵŵŝŶ͗ĐƌĞĂƟŶŝŶĞƌĂƟŽŝŶƚƌŽĚƵĐĞĚ ĂĚĚŝƟŽŶĂůǀĂƌŝĂďŝůŝƚLJŝŶĐŚŝůĚƌĞŶ͕ĂŶĚƚŚĞƌĞĨŽƌĞĂƉƉĞĂƌƐƚŽďĞĂůĞƐƐƉƌĞĐŝƐĞŵĞĂƐƵƌĞŵĞŶƚ ƚŚĂŶƚŚĞƵƐĞŽĨĂůďƵŵŝŶĐŽŶĐĞŶƚƌĂƟŽŶĂůŽŶĞ͘dŚŝƐůĂƌŐĞƌǀĂƌŝĂďŝůŝƚLJĐŽƵůĚŶŽƚďĞĞdžƉůĂŝŶĞĚ ďLJĂůĂƌŐĞƌǀĂƌŝĂďŝůŝƚLJŽĨƵƌŝŶĂƌLJĐƌĞĂƟŶŝŶĞŝƚƐĞůĨ͕ŶŽƌĐŽƵůĚŽƚŚĞƌĞdžƉůĂŶĂƟŽŶƐĨŽƌƚŚŝƐ ĚŝīĞƌĞŶĐĞďĞĞŶĨŽƵŶĚ͘&ƵƌƚŚĞƌƐƚƵĚŝĞƐŝŶƚŽƚŚĞĐƌĞĂƟŶŝŶĞŵĞĂƐƵƌĞŵĞŶƚŝƚƐĞůĨĂƐǁĞůůĂƐ ŝŶƚŽƚŚĞŝŶŇƵĞŶĐĞŽĨŵƵƐĐůĞŵĂƐƐŽŶƚŚĞƵƐĞŽĨƵƌŝŶĞĐƌĞĂƟŶŝŶĞĐŽƌƌĞĐƟŽŶƐĂƌĞŶĞĞĚĞĚƚŽ ƐƚĂŶĚĂƌĚŝnjĞĂůďƵŵŝŶƵƌŝĂŵĞĂƐƵƌĞŵĞŶƚƐĂŶĚĚĞĮŶĞĐƵƚͲŽīǀĂůƵĞƐĨŽƌĂůďƵŵŝŶ͗ĐƌĞĂƟŶŝŶĞ ƌĂƟŽ͛ƐŝŶĐŚŝůĚƌĞŶ͘dĂŬŝŶŐƚŚĞĮŶĚŝŶŐƐŽĨƚŚŝƐĐŚĂƉƚĞƌŝŶƚŽĂĐĐŽƵŶƚ͕ŝƚƐŚŽƵůĚďĞĂĚǀŝƐĞĚƚŽ ŵĞĂƐƵƌĞĂůďƵŵŝŶĐŽŶĐĞŶƚƌĂƟŽŶŝŶŵƵůƟƉůĞĮƌƐƚŵŽƌŶŝŶŐǀŽŝĚƵƌŝŶĞƐĂŵƉůĞƐ͕ƌĞƉĞĂƚĞĚ ŽǀĞƌƟŵĞ͕ŝŶŽƌĚĞƌƚŽŵĞĂƐƵƌĞĂŶĚŵŽŶŝƚŽƌĂůďƵŵŝŶƵƌŝĂŝŶƚŽĚĚůĞƌƐ͘

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

Processed on: 17-4-2018 PDF page: 104PDF page: 104PDF page: 104PDF page: 104

104 Chapter 7 sĞƌLJĨĞǁĚĂƚĂĂƌĞĂǀĂŝůĂďůĞƌĞŐĂƌĚŝŶŐƚŚĞĞīĞĐƚŽĨĂůďƵŵŝŶƵƌŝĂůŽǁĞƌŝŶŐŽŶƌĞŶĂů ĚŝƐĞĂƐĞƉƌŽŐƌĞƐƐŝŽŶŝŶĐŚŝůĚƌĞŶǁŝƚŚĐŚƌŽŶŝĐŬŝĚŶĞLJĚŝƐĞĂƐĞ͘/ŶChapter 5͕ƚŚĞŝŶŝƟĂů ƉƌŽƚĞŝŶƵƌŝĂ ůŽǁĞƌŝŶŐ ĞīĞĐƚ ŽĨ ƐƚĂŶĚĂƌĚŝnjĞĚ  ŝŶŚŝďŝƟŽŶ ĂŶĚ ŝƚƐ ĂƐƐŽĐŝĂƟŽŶ ǁŝƚŚ ƐƵďƐĞƋƵĞŶƚƌĞŶĂůĚŝƐĞĂƐĞƉƌŽŐƌĞƐƐŝŽŶǁĞƌĞĞǀĂůƵĂƚĞĚŝŶϮϴϬĐŚŝůĚƌĞŶǁŝƚŚ<͘/ŶƚŚŝƐ ƉŽƐƚͲŚŽĐĂŶĂůLJƐŝƐŽĨƚŚĞ^WƐƚƵĚLJ͕ŝƚǁĂƐƐŚŽǁŶƚŚĂƚƌĂŵŝƉƌŝůƚƌĞĂƚŵĞŶƚǁŝƚŚĂ ĚŽƐĞŽĨϲŵŐͬŵ2ͬĚĂLJůŽǁĞƌĞĚƉƌŽƚĞŝŶƵƌŝĂǁŝƚŚĂŵĞĂŶŽĨϰϮй͕ǁŝƚŚĂůĂƌŐĞǀĂƌŝĂďŝůŝƚLJ ďĞƚǁĞĞŶŝŶĚŝǀŝĚƵĂůƐ͘ŚŝůĚƌĞŶǁŝƚŚŵŽƌĞŝŶŝƟĂůƉƌŽƚĞŝŶƵƌŝĂƌĞĚƵĐƟŽŶǁĞƌĞĂƚůŽǁĞƌ ƌŝƐŬĨŽƌĚĞǀĞůŽƉŝŶŐƚŚĞĐŽŵƉŽƐŝƚĞƌĞŶĂůĞŶĚƉŽŝŶƚ;хϱϬйĞ'&ZĚĞĐůŝŶĞŽƌƉƌŽŐƌĞƐƐŝŽŶ ƚŽĞŶĚƐƚĂŐĞƌĞŶĂůĚŝƐĞĂƐĞͿ͕ǁŚŝĐŚŝƐŝŶůŝŶĞǁŝƚŚĮŶĚŝŶŐƐŝŶĂĚƵůƚƐ͘DŽƌĞŽǀĞƌ͕ŚŝŐŚĞƌ ůĞǀĞůƐŽĨďŽƚŚƌĞƐŝĚƵĂůƉƌŽƚĞŝŶƵƌŝĂĂŌĞƌĂƩĂŝŶŝŶŐƚŚĞĨƵůůĚŽƐĞŽĨƌĂŵŝƉƌŝů͕ĂŶĚƚŚĞƚŽƚĂů ĞdžƉŽƐƵƌĞƚŽƉƌŽƚĞŝŶƵƌŝĂĚƵƌŝŶŐĨŽůůŽǁͲƵƉ͕ǁĞƌĞĂƐƐŽĐŝĂƚĞĚǁŝƚŚĂŚŝŐŚĞƌƌŝƐŬŽĨ< ƉƌŽŐƌĞƐƐŝŽŶ͘/ŵƉŽƌƚĂŶƚůLJ͕ƚŚĞƐĞĮŶĚŝŶŐƐǁĞƌĞŝŶĚĞƉĞŶĚĞŶƚŽĨƚŚĞƵŶĚĞƌůLJŝŶŐĚŝƐĞĂƐĞ͕ ďĂƐĞůŝŶĞƉƌŽƚĞŝŶƵƌŝĂĂŶĚďůŽŽĚƉƌĞƐƐƵƌĞĐŽŶƚƌŽů͘ŽůůĞĐƟǀĞůLJ͕ƚŚĞƐĞĚĂƚĂŚŝŐŚůŝŐŚƚƚŚĞ ŝŵƉŽƌƚĂŶĐĞŽĨƉƌŽƚĞŝŶƵƌŝĂĂƐĂƌŝƐŬĨĂĐƚŽƌĨŽƌƌĞŶĂůĚŝƐĞĂƐĞƉƌŽŐƌĞƐƐŝŽŶŝŶĐŚŝůĚƌĞŶǁŝƚŚ <ĂŶĚƐƵŐŐĞƐƚƚŚĂƚƉƌŽƚĞŝŶƵƌŝĂůŽǁĞƌŝŶŐŝƐĂŶŝŵƉŽƌƚĂŶƚƚĂƌŐĞƚŝŶƚŚĞŵĂŶĂŐĞŵĞŶƚŽĨ ĐŚŝůĚƌĞŶǁŝƚŚ<ƚŽƉƌŽƚĞĐƚƚŚĞŝƌŬŝĚŶĞLJĨƵŶĐƟŽŶ͘ Chapter 6 ĚĞĮŶĞƐƚŚĞĞīĞĐƚŽĨĚŝƐĐŽŶƟŶƵĂƟŽŶŽĨZ^ŝŶŚŝďŝƟŽŶŽŶŝŵƉŽƌƚĂŶƚƌĞŶĂů ŵĂƌŬĞƌƐĂŶĚƌĞŶĂůĚŝƐĞĂƐĞƉƌŽŐƌĞƐƐŝŽŶŝŶĐŚŝůĚƌĞŶǁŝƚŚ<͘hƐŝŶŐŽďƐĞƌǀĂƟŽŶĂůĚĂƚĂ ĨƌŽŵƚŚĞϰƐƚƵĚLJ͕ŝŶŝƟĂůĐŚĂŶŐĞƐŝŶďůŽŽĚƉƌĞƐƐƵƌĞ͕ĂůďƵŵŝŶƵƌŝĂĂŶĚƉŽƚĂƐƐŝƵŵĂŶĚ ƚŚĞƌĂƚĞŽĨĞ'&ZĚĞĐůŝŶĞǁĞƌĞƚĞƐƚĞĚŝŶϲϵĐŚŝůĚƌĞŶǁŚŽĚŝƐĐŽŶƟŶƵĞĚZ^ŝŶŚŝďŝƟŽŶ ĚƵƌŝŶŐŽďƐĞƌǀĂƟŽŶ͘KŶƚŚĞƐŚŽƌƚƚĞƌŵ͕ĚŝƐĐŽŶƟŶƵĂƟŽŶŽĨZ^ŝŶŚŝďŝƟŽŶǁĂƐĨŽůůŽǁĞĚ ďLJĂŶŝŶĐƌĞĂƐĞŝŶĂůďƵŵŝŶƵƌŝĂĂŶĚĚĞĐƌĞĂƐĞŝŶƐĞƌƵŵƉŽƚĂƐƐŝƵŵ͘dŚĞƌĂƚĞŽĨĞ'&ZĚĞĐůŝŶĞ ďĞĐĂŵĞƐƚĞĞƉĞƌĂŌĞƌĚŝƐĐŽŶƟŶƵĂƟŽŶŽĨZ^ŝŶŚŝďŝƟŽŶ͕ƐƵŐŐĞƐƟŶŐƚŚĂƚƚŚĞƵƐĞŽĨ Z^ŝŶŚŝďŝƟŽŶǁĂƐƉƌŽƚĞĐƟǀĞĂŶĚƚŚĂƚĚŝƐĐŽŶƟŶƵĂƟŽŶĂĐĐĞůĞƌĂƚĞƐƚŚĞƉƌŽŐƌĞƐƐŝŽŶ ŽĨƌĞŶĂůĚŝƐĞĂƐĞƉƌŽŐƌĞƐƐŝŽŶ͘tĞĂůƐŽĞǀĂůƵĂƚĞĚƚŚĞŵŽƐƚĨƌĞƋƵĞŶƚĐůŝŶŝĐĂůƌĞĂƐŽŶƐ ĨŽƌĚŝƐĐŽŶƟŶƵĂƟŽŶŽĨZ^ŝŶŚŝďŝƟŽŶŝŶƚŚŝƐƐƚƵĚLJ͘dŚĞƐĞǁĞƌĞĂŶŝŶĐƌĞĂƐĞŝŶƐĞƌƵŵ ĐƌĞĂƟŶŝŶĞ͕ƐLJŵƉƚŽŵĂƟĐŚLJƉŽƚĞŶƐŝŽŶĂŶĚŚLJƉĞƌŬĂůĞŵŝĂ͘dŚŝƐƐƚƵĚLJŚĂƐĂƵŶŝƋƵĞĚĞƐŝŐŶ͕ ƵƐŝŶŐŽďƐĞƌǀĂƟŽŶĂůĚĂƚĂďĞĨŽƌĞĂŶĚĂŌĞƌĚŝƐĐŽŶƟŶƵĂƟŽŶŝŶŽƌĚĞƌƚŽĚĞĮŶĞƚŚĞĞīĞĐƚŽĨ ĚŝƐĐŽŶƟŶƵĂƟŽŶŽĨZ^ŝŶŚŝďŝƟŽŶŽŶƌĞŶĂůĚŝƐĞĂƐĞƉƌŽŐƌĞƐƐŝŽŶ͘ůƚŽŐĞƚŚĞƌ͕ƚŚĞƌĞƐƵůƚƐŽĨ ƚŚŝƐƐƚƵĚLJŝŶĚŝĐĂƚĞƚŚĂƚ͕ĂůƚŚŽƵŐŚƚŚĞƌĞŵĂLJďĞĐŽŵƉĞůůŝŶŐĐůŝŶŝĐĂůƌĞĂƐŽŶƐƚŽĚŝƐĐŽŶƟŶƵĞ Z^ŝŶŚŝďŝƟŽŶŝŶĐŚŝůĚƌĞŶǁŝƚŚ<͕ƚŚŝƐŵĞĂƐƵƌĞŝƐĂƐƐŽĐŝĂƚĞĚǁŝƚŚĂŶĂĐĐĞůĞƌĂƟŽŶŽĨ ƌĞŶĂůĨƵŶĐƟŽŶĚĞĐůŝŶĞ͘dŚĞƌĞĨŽƌĞ͕ƐƚŽƉƉŝŶŐƚŚŝƐƚŚĞƌĂƉLJĞǀĞŶĨŽƌŐŽŽĚĐůŝŶŝĐĂůƌĞĂƐŽŶƐ ƐŚŽƵůĚďĞǁĞŝŐŚĞĚĂŐĂŝŶƐƚƚŚĞŶĞŐĂƟǀĞŝŵƉĂĐƚŽŶůŽŶŐƚĞƌŵƌĞŶĂůĨƵŶĐƟŽŶ͘

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

Processed on: 17-4-2018 PDF page: 105PDF page: 105PDF page: 105PDF page: 105

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

Processed on: 17-4-2018 PDF page: 106PDF page: 106PDF page: 106PDF page: 106

106 Chapter 7 ĚĞƐĐƌŝďĞƐƐĂĨĞƚLJĂŶĚĞĸĐĂĐLJŽĨƚƌĞĂƚŵĞŶƚŝŶƚŚŝƐƉŽƉƵůĂƟŽŶ͘tŝƚŚƚŚĞƵƐĞŽĨƉƌĂŐŵĂƟĐ ƚƌŝĂůƐ͕ƌĞƐĞĂƌĐŚƋƵĞƐƟŽŶƐĐĂŶďĞĞdžƉůŽƌĞĚǁŚĞƌĞĐůŝŶŝĐĂůƚƌŝĂůĞǀŝĚĞŶĐĞŝƐůŝŵŝƚĞĚ͘dŚĞ ĐŚĂƉƚĞƌƐŝŶƉĂƌƚϮŽĨƚŚŝƐƚŚĞƐŝƐĂƌĞƚǁŽĞdžĂŵƉůĞƐŽĨŚŽǁĂŵŽƌĞƉƌĂŐŵĂƟĐƚƌŝĂůĚĞƐŝŐŶ ĐĂŶďĞĞdžĞĐƵƚĞĚ͘ /ŶĐŽŶĐůƵƐŝŽŶ͕ŵŽƌĞƐƚƵĚŝĞƐƐŚŽƵůĚďĞĐŽŶĚƵĐƚĞĚƚŽƵŶƌĂǀĞůƚŚĞ ŝŵƉŽƌƚĂŶĐĞŽĨ ĂůďƵŵŝŶƵƌŝĂĂƐĂƌŝƐŬŵĂƌŬĞƌŽĨĚŝƐĞĂƐĞ͕ƉƌĞƐĞŶƚĂůƌĞĂĚLJĞĂƌůLJŝŶůŝĨĞ͘ĐŽŵďŝŶĂƟŽŶŽĨ ŽďƐĞƌǀĂƟŽŶĂůĚĂƚĂĨƌŽŵĐŽŚŽƌƚƐƚƵĚŝĞƐĂŶĚĂƌĂŶĚŽŵŝnjĞĚĐŽŶƚƌŽůůĞĚƚƌŝĂůƐŚŽƵůĚŚĞůƉ ƵƐĨƵƌƚŚĞƌŝŶƚŚŝƐƋƵĞƐƚ͘

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

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