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University of Groningen Albuminuria: more than a renal risk marker? van den Belt, Sophie Mariëlle

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University of Groningen

Albuminuria: more than a renal risk marker?

van den Belt, Sophie Mariëlle

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

van den Belt, S. M. (2018). Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

Processed on: 17-4-2018 PDF page: 1PDF page: 1PDF page: 1PDF page: 1

Albuminuria: more than a renal risk marker?

About the prevalence, measurement and treatment of albuminuria in children

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

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Sophie M. van den Belt

Albuminuria: more than a renal risk marker? About the prevalence, measurement and treatment of albuminuria in children

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Processed on: 17-4-2018 PDF page: 3PDF page: 3PDF page: 3PDF page: 3

Albuminuria: more than a renal risk marker?

About the prevalence, measurement and treatment of albuminuria in children

WƌŽĞĨƐĐŚƌŝŌ

ƚĞƌǀĞƌŬƌŝũŐŝŶŐǀĂŶĚĞŐƌĂĂĚǀĂŶĚŽĐƚŽƌĂĂŶĚĞ ZŝũŬƐƵŶŝǀĞƌƐŝƚĞŝƚ'ƌŽŶŝŶŐĞŶ ŽƉŐĞnjĂŐǀĂŶĚĞ ƌĞĐƚŽƌŵĂŐŶŝĮĐƵƐƉƌŽĨ͘Ěƌ͘͘^ƚĞƌŬĞŶ ĞŶǀŽůŐĞŶƐďĞƐůƵŝƚǀĂŶŚĞƚŽůůĞŐĞǀŽŽƌWƌŽŵŽƟĞƐ͘ ĞŽƉĞŶďĂƌĞǀĞƌĚĞĚŝŐŝŶŐnjĂůƉůĂĂƚƐǀŝŶĚĞŶŽƉ ĚŝŶƐĚĂŐϮϮŵĞŝϮϬϭϴŽŵϭϭ͘ϬϬƵƵƌ door

Sophie Mariëlle van den Belt

ŐĞďŽƌĞŶŽƉϭϱĂƵŐƵƐƚƵƐϭϵϵϬ ƚĞ'ƌŽŶŝŶŐĞŶ

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Promotores WƌŽĨ͘Ěƌ͘͘ĚĞĞĞƵǁ WƌŽĨ͘Ěƌ͘,͘:͘>ĂŵďĞƌƐ,ĞĞƌƐƉŝŶŬ Beoordelingscommissie WƌŽĨ͘Ěƌ͘,͘:͘sĞƌŬĂĚĞ WƌŽĨ͘Ěƌ͘^͘W͘ĞƌŐĞƌ WƌŽĨ͘Ěƌ͘Z͘ŽǁĂƌĚ

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

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Paranimfen

sĂůĞŶƟŶĂ'ƌĂĐĐŚŝ ^ŝĞƚĂĚĞsƌŝĞƐ

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518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt 518800-L-sub01-bw-vdBelt Processed on: 17-4-2018 Processed on: 17-4-2018 Processed on: 17-4-2018

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Table of contents

ŚĂƉƚĞƌϭ /ŶƚƌŽĚƵĐƟŽŶĂŶĚŝŵƐŽĨdŚĞƐŝƐ 9

Part 1: The prevalence and measurement of albuminuria in children

ŚĂƉƚĞƌϮ WƌĞǀĂůĞŶĐĞĂŶĚĚŝƐƚƌŝďƵƟŽŶŽĨ;ŵŝĐƌŽͿĂůďƵŵŝŶƵƌŝĂŝŶ

toddlers 23

ŚĂƉƚĞƌϯ ŽŵƉĂƌŝƐŽŶŽĨƵƌŝŶĞĐŽůůĞĐƟŽŶŵĞƚŚŽĚƐĨŽƌ

albuminuria assessment in young children 39

ŚĂƉƚĞƌϰ How to measure and monitor albuminuria in healthy

toddlers 51

Part 2: The treatment of albuminuria in children

ŚĂƉƚĞƌϱ ĂƌůLJƉƌŽƚĞŝŶƵƌŝĂůŽǁĞƌŝŶŐďLJŝŶŚŝďŝƟŽŶƉƌĞĚŝĐƚƐ

renal survival in children with chronic kidney disease 65 ŚĂƉƚĞƌϲ ^ŚŽƵůĚZ^ŝŶŚŝďŝƟŽŶďĞĚŝƐĐŽŶƟŶƵĞĚŝŶĐŚŝůĚƌĞŶǁŝƚŚ

advanced chronic kidney disease? Results of the 4C study 87 ŚĂƉƚĞƌϳ ^ƵŵŵĂƌLJĂŶĚĨƵƚƵƌĞƉĞƌƐƉĞĐƟǀĞƐ 101 Appendices EĞĚĞƌůĂŶĚƐĞƐĂŵĞŶǀĂƫŶŐ Dankwoord

About the author

111 119 125

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