University of Groningen
Structural plasticity of the social brain
Patel, Deepika
DOI:
10.33612/diss.133472775
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Patel, D. (2020). Structural plasticity of the social brain: Social stress-induced adaptations in dendritic remodeling and behavior. University of Groningen. https://doi.org/10.33612/diss.133472775
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Structural plasticity of
the social brain
Social stress-induced adaptations in dendritic remodeling and
behavior
The research reported in this thesis was carried out in the expertise group “Behavioral Neurobiology” at the Groningen Institute for Evolutionary Life Sciences, Groningen, The Netherlands in collaboration with National Centre for Biological Sciences (NCBS), Bangalore, India, according to the requirements of the Graduate School of Science, Faculty of Science and Engineering, University of Groningen, The Netherlands.
This work was financially supported by the University of Groningen, The Netherlands and Department of Biotechnology, Government of India, India.
Cover design: Sandra Tukker, Ridderprint Printed by: Ridderprint, The Netherlands
Copyright © D. B. Patel 2020, Groningen, The Netherlands.
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.
Structural plasticity of the social
brain
Social stress-induced adaptations in dendritic remodeling and
behavior
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Friday 9 October 2020 at 16.15 hours
Supervisors
Prof. M.J.H. Kas Prof. S. ChattarjiCo-supervisor
Dr. B. BuwaldaAssessment Committee
Prof. G. van DijkProf. H. Kessels Prof. S. Spijker
To Papa and Mommy,
Who made me what I am…
CONTENTS
Chapter Content Page
1 General introduction and thesis overview 1 2 Repeated social stress leads to contrasting patterns of structural
plasticity in the amygdala and hippocampus 19 3 Single exposure to social defeat or immobilization stress fails to
induce lasting alterations in general anxiety and hippocampal neurogenesis in Wistar and wild-type Groningen rats
37 4 Repeated victorious and defeat experiences induce similar dendritic
spine remodeling in hippocampus, amygdala and prefrontal cortex of rats
53
5 Decreased spine density in posterodorsal medial amygdala neurons
of proactive coping rats 63
6 Sensory contact model induces differential expression of phosphorylated cofilin and cofilin proteins in dorsal hippocampus and amygdala in reactive and proactive WTG rats
75
7 Establishment of the social hierarchy in wild-type Groningen rats using the visible burrow system-a model of chronic social stress? 95 8 Social defeat of male intruder rats in a mixed-sex social colony as
an alternative for the resident-intruder paradigm 117
9 General Discussion 131
References 141
English Summary 165
Nederlandse Samenvatting 173
