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University of Groningen

Energy balance after bariatric surgery

Somogyi, Edit

DOI:

10.33612/diss.125435301

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Somogyi, E. (2020). Energy balance after bariatric surgery. University of Groningen. https://doi.org/10.33612/diss.125435301

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Energy balance after bariatric

surgery

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. C. Wijmenga

and in accordance with the decision by the College of Deans. This thesis will be defended in public on

Tuesday 26 May 2020 at 11:00 hours

by

Edit Somogyi

born on 7 December 1970

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Supervisors

Prof. G. van Dijk Prof. C.J. Nyakas

Co-supervisor

Prof. A. van Beek

Assessment Committee

Prof. F. Kuipers Prof. A.J. Moshage Prof. E.J. Hazebroek

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The research reported in this thesis was carried out at the Department of Behavioral Neuroscience; Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, the Netherlands and at the Gastrointestinal Research Group, Departement of Physiology, Faculty of Medicine at the University of Calgary, Canada. All studies were approved by the Ethical Committee of the University of Groningen and by the Animal Resource Care Centre of University of Calgary and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Production of the thesis was partialy funded by PhD scholarship of Higher Education Institutional Excellence Program at Semmelweis University, Hungary, by an Erasmus Campus Mundi fellowship and by the University of Groningen.

Layout, cover, figures Edit Somogyi

Prined by Zalsman Groningen

ISBN: 978-94-034-2633-4 (printed) ISBN: 978-94-034-2632-7 (digital)

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Table of Contents

Chapter 1 General introduction 9

Chapter 2 Ileal transposition; a non-restrictive bariatric surgical procedure 30 that reduces body fat and increases ingestion-related energy

expenditure in rats

Chapter 3 High protein diet is most effective to reduce body weight after 67 ileal transposition

Chapter 4 Ileal transposition in rats reduces resting metabolic rate 102 irrespective of nutritional state or macronutrient

composition of the diet

Chapter 5 17-hour postingestive PYY level correlates with body 130 weight loss following ileal transposition

Chapter 6 Rats feeding a high fat high sugar diet have reduced 163 temperature and locomotor disturbances following

RYGB surgery

Chapter 7 General discussion 192

Nederlandse samenvatting 226

Acknowledgements 244

Curriculum vitae 246

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