University of Groningen
Pre-clinical investigation of brain mechanisms associated with Parkinson’s disease: The impact of diet
Reali Nazario, Luiza
DOI:
10.33612/diss.130756082
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
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Reali Nazario, L. (2020). Pre-clinical investigation of brain mechanisms associated with Parkinson’s disease: The impact of diet. University of Groningen. https://doi.org/10.33612/diss.130756082
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Pre-clinical investigation of brain mechanisms
associated with Parkinson’s disease:
The impact of diet
This thesis is valid for a double degree as a collaboration between the University of Groningen, the University Medical Center Groningen (UMCG), and the Pontifical Catholic University of Rio Grande do Sul (PUCRS). The work on this thesis has been carried out in the Department of Nuclear Medicine and Molecular Imaging of the UMCG, as well as in the Laboratory of Neurochemistry and Psychopharmacology of PUCRS.
The reported research contained in this thesis was financially supported by a scholarship from the Graduate School of Medical Sciences (Abel Tasman Talent Program) of the UMCG and from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil. Printing of this thesis was financially supported by the UMCG, and the research school of Behavioral and Cognitive Science (BCN).
Cover design and layout: Bob M J Knaapen and Luiza Reali Nazario Image artist: Bob M J Knaapen
Printing: Gildeprint
Dissertation of University of Groningen, Groningen, The Netherlands Dissertation of Pontifical Catholic University of Rio Grande do Sul, Brazil Copyright © 2020 Luiza Reali Nazario
Pre-clinical investigation of brain mechanisms
associated with Parkinson’s disease:
The impact of diet
PhD thesis
to obtain the degree of Doctor of the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans and
to obtain the degree of Doctor of Molecular and Cellular Biology of the Pontifical Catholic University of Rio Grande do Sul
on the authority of the
Rector Magnificus Prof. Evilázio Teixeira and in accordance with
the decision by the College of Deans Double degree PhD
This thesis will be defended in public on Tuesday 25 August 2020 at 18:00 hours
by
Luiza Reali Nazario
born on 20 December of 1990 in Porto Alegre
Supervisors
Prof. E.F.J. de Vries Prof. R. Souza da Silva Co-supervisors
Dr. J. Doorduin
Prof. C.M. Moriguchi Jeckel Assessment Committee Prof. G. van Dijk
Prof. C.A. Buchpiguel Prof. M.R.M.R. Vianna Prof. P.H. Elsinga
Paranymphs
Rodrigo Esteban Moraga-Amaro Débora Elisa Peretti
Table of Contents
Chapter 1 General introduction ...7
Chapter 2 Targeting Adenosine Signaling in Parkinson's Disease: From Pharmacological to Non-pharmacological Approaches………..33
Chapter 3 Evaluation of behavioural and biochemical parameters after an intra-encephalic injection of 6-OHDA in adult zebrafish………59
Chapter 4 In vivo PET imaging of zebrafish………..………....75
Chapter 5 The effect of a cafeteria diet on D2 receptor availability: a PET imaging study in rats. ……….……….95
Chapter 6 The influence of a high-fat diet on D2 receptor availability and behavior in a rat model of Parkinson’s disease.………..109
Chapter 7 A high-fat diet induces exacerbated neuroinflammation and altered gut microbiota in a preclinical model of Parkinson’s disease……….133
Chapter 8 Discussion and future perspectives………...………163
Chapter 9 English Summary………..………...…177
Chapter 10 Nederlandse Samenvatting………..…183
Chapter 11 Resumo em Português………...………..189
List of Publication………....195
About the Author………..197
