University of Groningen
Pre-clinical investigation of brain mechanisms associated with Parkinson’s disease: The impact of diet
Reali Nazario, Luiza
DOI:
10.33612/diss.130756082
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Reali Nazario, L. (2020). Pre-clinical investigation of brain mechanisms associated with Parkinson’s disease: The impact of diet. University of Groningen. https://doi.org/10.33612/diss.130756082
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Propositions
1. The purinergic system is a promising target for the development of new
treatment strategies for Parkinson’s disease.
2. Premature termination of clinical research with a new drug due to lack of efficacy, like in the case of Preladenant, often causes premature opinions about the drug target.
3. PET imaging of zebrafish is feasible and allows for identifying physiological changes, although several limitations have to be considered.
4. PET imaging is of great value for longitudinal and translational studies, as the same technique allows for non-invasive measurement of the disease course and evaluation of treatment effects in animal models and patients.
5. We are what we eat: Food changes our behavior and without restriction
can cause addictive symptoms.
6. Diet affects D2 receptor availability and microbiota composition and thus
could modify the course of Parkinson’s disease.
7. Increasing taxes on unhealthy food and implementing dietary prevention
programs could result in reduction of health care expenses.
8. Neuroinflammation and specific microbiota patterns are promising early biomarkers for Parkinson’s disease that could predict the disease onset before symptoms appear.
9. Besides genetic and environmental factors, it is often important to consider the lifestyle of the patient as well to complete the picture about the onset of a disease.
10. Like the launch of a space craft, the PhD trajectory is never easy, but can be enjoyable and beautiful.
11. The completion of a PhD thesis is never a task of just one person.
12. People can adapt their behavior to different circumstances, although the speed and extent of these adaptations are affected by cultural differences.
