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University of Groningen

Clinical and genetic factors associated with disease course in inflammatory bowel disease

Spekhorst, Lieke Maaike

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Spekhorst, L. M. (2018). Clinical and genetic factors associated with disease course in inflammatory bowel

disease. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Clinical and genetic factors associated with

disease course in inflammatory bowel disease

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L.M. Spekhorst

Clinical and genetic factors associated with disease course in inflammatory bowel disease

ISBN: 978-94-034-1106-4 (book) 978-94-034-1105-7 (ebook)

Cover design: Erwin Timmerman, Optima Grafische Communicatie Layout: Anna Bruijning, persoonlijkproefschrift.nl

Printed by: Ipskamp Printing, proefschriften.net

This thesis was financially supported by University Medical Center of Groningen, Graduate School of Medical Sciences, the University of Groningen, Nederlandse vereniging voor Gastro-enterologie (NVGE), Takeda Nederland, Ferring B.V., Dr. Falk Pharma Benelux B.V., Mylan Healthcare B.V., Teva Netherlands B.V., Norgine B.V., Tramedico B.V. en Pfizer.

Copyright© 2018 L.M. Spekhorst

All right reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.

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Clinical and genetic factors associated with

disease course in inflammatory bowel disease

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 14 november 2018 om 14.30 uur

door

Lieke Maaike Spekhorst

geboren op 24 augustus 1988 te Hengelo

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Promotores Prof. dr. R.K. Weersma Prof. dr. G. Dijkstra Copromotor Dr. E.A.M. Festen Beoordelingscommissie Prof. dr. H.W. Verspaget Prof. dr. H. Snieder Prof. dr. G.R.A.M. D’Haens

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Paranimfen

M.S. Spekhorst L.S. Spekhorst

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Table of contents

Chapter 1 Introduction and outline of this thesis

Part Ι. The epidemiology of IBD disease course: Identifying clinical factors that explain phenotypic differences in IBD patients

Chapter 2 Performance of the Montreal classification for inflammatory bowel diseases.

World J Gastroenterol 2014 Nov 7;20(41):15374-15381

Chapter 3 Cohort profile: Design and first results of the Dutch IBD Biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease.

BMJ Open 2017 Nov 8;7(11)

Chapter 4 Prevalence of- and risk factors for work disability in Dutch patients with inflammatory bowel disease.

World J Gastroenterol 2017 Dec 14;23(46):8182-8192

Chapter 5 The impact of ethnicity and country of birth on inflammatory bowel disease phenotype: a prospective cohort study.

J Crohns Colitis 2017 Dec 4;11(12):1463-1470

Chapter 6 Sex-related differences in patients with inflammatory bowel disease; results of two prospective cohort studies.

Inflamm Bowel Dis 2018 May 18;24(6):1298-1306

9 19 33 59 79 99

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Part II. The genetics of IBD disease course: Identifying genetic risk loci that are associated with IBD disease behaviour

Chapter 7 Down the line from genome-wide association studies in inflammatory bowel disease: the resulting clinical benefits and the outlook for the future. Expert Rev Clin Immunol 2015 Jan;11(1):33-44

Chapter 8 Identification of clinical and genetic parameters associated with hidradenitis suppurativa in inflammatory bowel disease.

Inflamm Bowel Dis 2016 Jan;22(1):106-13

Chapter 9 Genomic and expression analyses identify a disease modifying variant for fibrostenotic Crohn’s disease.

J Crohns Colitis 2018 Apr 27;12(5):582-588

Chapter 10 Immunogenicity to anti-TNFα: a non-HLA association. Manuscript in preparation

Chapter 11 Conclusions, Discussion and Future Perspectives

Appendix Samenvatting Dankwoord Curriculum vitae List of publications 115 139 157 173 187 200 205 209 210

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