Cover Page
The handle
https://hdl.handle.net/1887/3142382
holds various files of this Leiden
University dissertation.
Author: Groen, E.J.
Title: The road towards conquering DCIS overtreatment
Issue Date:
2021-02-16
551586-L-st-Groen 551586-L-st-Groen 551586-L-st-Groen 551586-L-st-Groen Processed on: 18-12-2020 Processed on: 18-12-2020 Processed on: 18-12-2020
Processed on: 18-12-2020 PDF page: 1PDF page: 1PDF page: 1PDF page: 1
Stellingen behorende bij het proefschrift
The road towards conquering DCIS overtreatment
1. Despite their better prognosis, DCIS patients have comparable perceptions of the risk of recurrence and dying of breast cancer as women with invasive breast cancer
(van Gestel et al. Eur J Cancer 2007)
2. Realistic risk perception is essential to reduce overtreatment in DCIS 3. Today’s DCIS is different from yesterday’s
4. Treatment decisions in DCIS cannot be based on histopathological factors alone (this thesis) 5. Prognostic histopathological factors in invasive breast cancer also have prognostic value in DCIS
(this thesis)
6. A gold standard should be based on biology and not on an expert’s opinion 7. In the case of DCIS, ignorance may be bliss
8. Having the disease DCIS does not make women ill
9. The much higher incidence of invasive breast cancer compared to DCIS and the frequent finding of DCIS adjacent to invasive breast cancer, suggests an undetected DCIS reservoir exists 10. Most invasive breast cancers we miss during the diagnostic work-up of DCIS have a good
prognosis, very likely also upon delayed detection (this thesis)
11. The presence of extensive DCIS adjacent to HER2-positive invasive breast cancer should not exclude the option of breast-conserving surgery (this thesis)
