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Cover Page

The handle

https://hdl.handle.net/1887/3142382

holds various files of this Leiden

University dissertation.

Author: Groen, E.J.

Title: The road towards conquering DCIS overtreatment

Issue Date:

2021-02-16

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551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen Processed on: 18-12-2020 Processed on: 18-12-2020 Processed on: 18-12-2020

Processed on: 18-12-2020 PDF page: 1PDF page: 1PDF page: 1PDF page: 1

The road towards conquering

DCIS overtreatment

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551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen Processed on: 18-12-2020 Processed on: 18-12-2020 Processed on: 18-12-2020

Processed on: 18-12-2020 PDF page: 2PDF page: 2PDF page: 2PDF page: 2 The work described in this thesis was performed at the Netherlands Cancer Institute – Antoni van

Leeuwenhoek, Amsterdam, the Netherlands. In cooperation with Leiden University Medical Center, the Netherlands Comprehensive Cancer Organisation (IKNL), the nationwide network and registry of histo- and cytopathology in the Netherlands (PALGA) and the Dutch breast cancer screening organi-sation (BOB).

The research was supported by KWF Kankerbestrijding (grant number NKI2014-7167) and by Cancer Research UK and by KWF Kankerbestrijding in a joint grant (grant number C38317/A24043).

Financial support for publication of this thesis was kindly provided by the Netherlands Cancer Institute.

Layout: Wendy Bour-van Telgen

Printed by: Gildeprint, Enschede, the Netherlands ISBN: 978-94-6402-268-1

Copyright© 2020 E.J. Groen, Amsterdam, the Netherlands

All rights preserved. No part of this publication may be reproduced, stored in an archival system, or transmitted in any form or by any means, without prior permission of the copyright owner.

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551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen Processed on: 18-12-2020 Processed on: 18-12-2020 Processed on: 18-12-2020

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The road towards conquering

DCIS overtreatment

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.dr.ir. H. Bijl, volgens besluit

van het College voor Promoties te verdedigen op dinsdag 16 februari 2021

klokke 15.00 uur

door

Emma Josephine Groen

geboren te Leiden in 1981

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551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen Processed on: 18-12-2020 Processed on: 18-12-2020 Processed on: 18-12-2020

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Promotor

prof. dr. J. Wesseling Copromotoren

dr. E.H. Lips NKI-AVL

dr. M. Schaapveld NKI-AVL

Leden promotiecommissie

prof. dr. V.T.H.B.M. Smit prof. dr. J.E.A. Portielje

prof. dr. ir. M.K. Schmidt

prof. dr. M.J. van de Vijver AUMC-UvA prof. dr. E.J.Th. Rutgers AUMC-UvA

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551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen Processed on: 18-12-2020 Processed on: 18-12-2020 Processed on: 18-12-2020

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Table of contents

Thesis outline

Chapter 1 Finding the balance between over- and under-treatment of ductal carcinoma in situ (DCIS)

Chapter 2 Ductaal carcinoma in situ: de balans tussen over- en onderbehandeling

Chapter 3 Predictors of an invasive breast cancer recurrence after DCIS: A systematic review and meta-analyses

Chapter 4 Reliability of preoperative breast biopsies showing ductal carcinoma in situ and implications for non-operative treatment: a cohort study

Chapter 5 Prognostic value of histopathological DCIS features in a large-scale international interrater reliability study

Chapter 6 Pathologic response of ductal carcinoma in situ to neoadjuvant systemic treatment in HER2-positive breast cancer

Chapter 7 Summarizing discussion

Appendices Nederlandse samenvatting Intraductal papillary carcinoma List of publications Acknowledgments (Dankwoord) Curriculum Vitae 7 11 37 51 85 111 143 167 183 193 203 209 213

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