Cover Page
The handle
https://hdl.handle.net/1887/3142382
holds various files of this Leiden
University dissertation.
Author: Groen, E.J.
Title: The road towards conquering DCIS overtreatment
Issue Date:
2021-02-16
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The road towards conquering
DCIS overtreatment
551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen 551586-L-bw-Groen Processed on: 18-12-2020 Processed on: 18-12-2020 Processed on: 18-12-2020
Processed on: 18-12-2020 PDF page: 2PDF page: 2PDF page: 2PDF page: 2 The work described in this thesis was performed at the Netherlands Cancer Institute – Antoni van
Leeuwenhoek, Amsterdam, the Netherlands. In cooperation with Leiden University Medical Center, the Netherlands Comprehensive Cancer Organisation (IKNL), the nationwide network and registry of histo- and cytopathology in the Netherlands (PALGA) and the Dutch breast cancer screening organi-sation (BOB).
The research was supported by KWF Kankerbestrijding (grant number NKI2014-7167) and by Cancer Research UK and by KWF Kankerbestrijding in a joint grant (grant number C38317/A24043).
Financial support for publication of this thesis was kindly provided by the Netherlands Cancer Institute.
Layout: Wendy Bour-van Telgen
Printed by: Gildeprint, Enschede, the Netherlands ISBN: 978-94-6402-268-1
Copyright© 2020 E.J. Groen, Amsterdam, the Netherlands
All rights preserved. No part of this publication may be reproduced, stored in an archival system, or transmitted in any form or by any means, without prior permission of the copyright owner.
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The road towards conquering
DCIS overtreatment
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.dr.ir. H. Bijl, volgens besluit
van het College voor Promoties te verdedigen op dinsdag 16 februari 2021
klokke 15.00 uur
door
Emma Josephine Groen
geboren te Leiden in 1981
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Promotor
prof. dr. J. Wesseling Copromotoren
dr. E.H. Lips NKI-AVL
dr. M. Schaapveld NKI-AVL
Leden promotiecommissie
prof. dr. V.T.H.B.M. Smit prof. dr. J.E.A. Portielje
prof. dr. ir. M.K. Schmidt
prof. dr. M.J. van de Vijver AUMC-UvA prof. dr. E.J.Th. Rutgers AUMC-UvA
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Table of contents
Thesis outline
Chapter 1 Finding the balance between over- and under-treatment of ductal carcinoma in situ (DCIS)
Chapter 2 Ductaal carcinoma in situ: de balans tussen over- en onderbehandeling
Chapter 3 Predictors of an invasive breast cancer recurrence after DCIS: A systematic review and meta-analyses
Chapter 4 Reliability of preoperative breast biopsies showing ductal carcinoma in situ and implications for non-operative treatment: a cohort study
Chapter 5 Prognostic value of histopathological DCIS features in a large-scale international interrater reliability study
Chapter 6 Pathologic response of ductal carcinoma in situ to neoadjuvant systemic treatment in HER2-positive breast cancer
Chapter 7 Summarizing discussion
Appendices Nederlandse samenvatting Intraductal papillary carcinoma List of publications Acknowledgments (Dankwoord) Curriculum Vitae 7 11 37 51 85 111 143 167 183 193 203 209 213
