VU Research Portal
A Slow Progressive MPTP Marmoset Model for Idiopathic Parkinson's Disease
Franke, S.K.
2016
document version
Publisher's PDF, also known as Version of record
Link to publication in VU Research Portal
citation for published version (APA)
Franke, S. K. (2016). A Slow Progressive MPTP Marmoset Model for Idiopathic Parkinson's Disease: Behaviour,
Pathology and Proteomics.
General rights
Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain
• You may freely distribute the URL identifying the publication in the public portal ?
Take down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
E-mail address:
vuresearchportal.ub@vu.nl
A SLOW PROGRESSIVE MPTP MARMOSET
MODEL FOR IDIOPATHIC PARKINSON’S DISEASE
BEHAVIOUR, PATHOLOGY AND PROTEOMICS
Cover: “M&M” a painting by Katka Szilagyi Printed: Optima Grafische Communicatie BV ISBN: 978-94-6169-832-2
The research discribed in this thesis was performed at the Biomedical Primate Research Centre in Rijswijk and the Center for Neurogenomics and Cognitive Research at Vrije Universiteit Amsterdam.
This research was supported by grants from the Parkinson Vereniging, Biomedical Primate Research Centre and Center for Neurogenomics and Cognitive Research.
Printing of this thesis was financially supported by Vrije Universiteit Amsterdam, Parkinson Vereniging, Abbvie, Center for Neurogenomics and Cognitive Research
A SLOW PROGRESSIVE MPTP MARMOSET
MODEL FOR IDIOPATHIC PARKINSON’S DISEASE
BEHAVIOUR, PATHOLOGY AND PROTEOMICS
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad Doctor aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus
prof.dr. V. Subramaniam, in het openbaar te verdedigen ten overstaan van de promotiecommissie van de Faculteit der Aard- en Levenswetenschappen
op dinsdag 10 mei 2016 om 11.45 uur in de aula van de universiteit,
De Boelelaan 1105
Door
Sigrid Karen Franke
promotor: prof. dr. A.B. Smit
“Learn from yesterday,
live for today and
hope for tomorrow”
-beoordelingscommissie: prof. dr. B. ’t Hart prof. B. Spruijt dr. N. Verhave dr. W.D.J. van der Berg
dr. M. Loos paranimfen: A.L.F. van Deijk
TABLE OF CONTENTS
CHAPTER 1: GENERAL INTRODUCTION . . . .11
Parkinson’s disease . . . 13
Animal models of pd . . . 16
Pd research in marmosets. . . 19
Aims and outline . . . 21
CHAPTER 2: PROGRESSION AND RECOVERY OF PARKINSONISM IN A CHRONIC PROGRESSIVE MPTP-INDUCTION MODEL INTHE MARMOSET WITHOUT PERSISTENT MOLECULAR AND CELLULAR DAMAGE . . . .25
Abstract . . . 26
Introduction . . . 27
Experimental procedures . . . 28
Results . . . 33
Discussion . . . 40
CHAPTER 3: INDIVIDUAL AND FAMILIAL SUSCEPTIBILITY TO MPTP IN A COMMON MARMOSET MODEL FOR PARKINSON’S DISEASE . . . .45
Abstract . . . 46
Introduction . . . 47
Methods . . . 48
Results . . . 52
Discussion . . . 58
CHAPTER 4: PROTEOME ANALYSIS OF PUTAMEN AND SUBSTANTIA NIGRA IN THE COMMON MARMOSET FOLLOWING ACUTE AND CHRONIC MPTP EXPOSURE . . . .61 Abstract . . . 62 Introduction . . . 63 Experimental procedures . . . 64 Results . . . 67 Discussion . . . 75
CHAPTER 5: SWATH DATA ANALYSIS OF THE MARMOSET AND HUMAN HIPPOCAMPAL SYNAPTOSOME FRACTION: EVALUATION OF TECHNICAL VARIATION IN PROTEOMIC ANALYSIS . . . .79
Abstract . . . 80
Introduction . . . 81
Material and methods . . . 83
Results . . . 86
CHAPTER 6: GENERAL DISCUSSION . . . .93 CHAPTER 7: SUMMARY . . . . 103 English summary . . . 105 Nederlandse samenvatting. . . 108 ABBREVIATIONS . . . . 113 REFERENCES . . . . 119
ABOUT THE AUTHOR . . . . 141
