Differences in cellular immunity between humans and chimpanzees in relation to their relative resistance to aids
Rutjens, E.D.I.
Citation
Rutjens, E. D. I. (2011, February 3). Differences in cellular immunity between humans and chimpanzees in relation to their relative resistance to aids. Retrieved from
https://hdl.handle.net/1887/16435
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Differences in cellular immunity between humans and chimpanzees in relation to
their relative resistance to AIDS.
Proefschrift
ter verkrijging van
de graad van Doctor aan de universiteit van Leiden,
op gezag van de Rector Magnificus prof. mr. P. F. van der Heijden, volgens besluit van het college voor promoties
te verdedigen op Donderdag 3 Februari 2011 klokke 15.00 uur
door
Erik Dirk Ivo Rutjens geboren te Heerlen
in 1978
Promotiecommissie
Promotores : prof . dr. C. J. M. Melief
prof. dr. J.L. Heeney, University of Cambridge, UK
Co-promotor : dr. G. Koopman, Biomedical Primate Research Centre
Overige leden : prof. dr. T. H. M. Ottenhoff prof. dr. F. Koning
prof. dr. E. J. H. J. Wierz, UMC Utrecht prof. dr. J.C. Wilschut, UMC Groningen
prof. dr. F. M. Gotch, Imperial college,London, UK
The studies described in this thesis were conducted at the department of Virology of Biomedical Primate Research Centre, Rijswijk, The Netherlands and at the University of Genova, Italy.
The printing of this thesis was financially supported by:
Biomedical Primate Research Centre Rijswijk University Leiden
Printing: Wöhrmann Print Service, Zutphen, the Netherlands ISBN: 978-90-8570-717-2
Rutjens, Erik, D.I.
Differences in cellular immunity between humans and chimpanzees in relation to their relative resistance to AIDS.
Proefschrift Leiden
© Erik Rutjens 2011
No part of this thesis may be reproduced or transmitted in any form or by any means, without written permission of the author
The painting on the cover of this thesis was kindly provided by Marianne Marbo.
Contents
Chapter 1 Introduction 7
Chapter 2 Lentivirus infections and mechanisms of disease resistance in chimpanzees
21
Chapter 3 Transmission of simian immunodificiency virus SIVcpz and the
evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees
47
Chapter 4 Chimpanzee CD4+ T cells are relatively insensitive to HIV-1 envelope mediated inhibition of CD154 upregulation
75
Chapter 5 Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals
95
Chapter 6 CD8+ NK cells are predominant in chimpanzees and characterized by high NCR expression cytokine production and are preserved in chronic HIV-1 infection
123
Chapter 7 NKp44 expression, phylogenesis and function in non-human primate NK cells
147
Chapter 8 General discussion 175
Chapter 9 Summary 185
Chapter 10 Nederlandse samenvatting 191
Publications 199
Curriculum vitae 201
