University of Groningen
Epstein-Barr virus-associated malignancies
Tan, Geok Wee
DOI:
10.33612/diss.173425402
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Tan, G. W. (2021). Epstein-Barr virus-associated malignancies: Susceptibility factors and molecular detection in liquid biopsies. University of Groningen. https://doi.org/10.33612/diss.173425402
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Propositions Belonging to the PhD thesis Epstein-Barr virus-associated malignancies Susceptibility factors and molecular detection in liquid biopsies
1. Susceptibility effects of HLA alleles are early events in pathogenesis, while the pressure on tumor cells to downregulate HLA is most likely related to emerging immune responses later on. (this thesis, chapter 3)
2. The Bidayuh, a minority population in Malaysia, have a distinct set of HLA alleles conferring risk to the development of nasopharyngeal carcinoma. (this thesis, chapter 4)
3. Biomarkers for nasopharyngeal carcinoma can be detected by non-invasive sampling in the form of nasal washings. (this thesis, chapter 6)
4. Despite the scarcity of tumor cells in Hodgkin lymphoma, copy number variations and EBV can be detected in cell-free DNA obtained at the time of diagnosis. (this thesis, chapter 7)
5. EBV-positive Hodgkin lymphomas are less dependent on activation of NF-κB pathway genes through copy number alterations. (this thesis, chapter 7)
6. Copy number variations detected in cell-free DNA of PTLD patients reflect those of biopsy tissue, indicating the presence of circulating tumor DNA. (this thesis, chapter 8)
7. Satisfaction lies in the effort, not in the attainment. (Mahatma Gandhi)
8. Success is not final; failure is not fatal. It is the courage to continue that counts. (Winston S. Churchill)
