Adoptive T cell therapy as treatment for Epstein Barr Virus-associated malignancies : strategies to enhance potential and broaden application

Propositions Belonging to the PhD thesis Epstein-Barr virus-associated malignancies Susceptibility factors and molecular detection in liquid biopsies. Susceptibility effects of

Door gebruik te maken van dendritische cellen voor reactivatie, en van EBV- getransformeerde B-cellen die het tumorantigeen tot overexpressie brengen voor expansie, kan een

The infused lines contained cytotoxic T-cells specific for LMP2 (an EBV antigen usually expressed by NPC tumor cells), and were biologi- cally active , reducing levels of EBV DNA

Immunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with

Using a peptide library spanning the entire LMP2 sequence, 25 CTL lines from patients with EBV-positive malignancies expressing type II latency were screened for the presence

Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T-cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with

Figure 7d compares the percentage of tetramer positive CD8+ cells specific for the HLA 11*01 restricted LMP2 peptide SSC and the HLA A29*01 restricted LMP2 peptide ILL with HLA

We hypothesized that antigen engagement of a chimeric antigen receptor linked to an en- domain supplying CD3 ζ, CD28 and OX40 signals in cis would produce sustained activation,