Epstein-Barr virus-associated malignancies
Tan, Geok Wee
DOI:
10.33612/diss.173425402
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Tan, G. W. (2021). Epstein-Barr virus-associated malignancies: Susceptibility factors and molecular detection in liquid biopsies. University of Groningen. https://doi.org/10.33612/diss.173425402
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Epstein‐Barr virus‐associated malignancies
Susceptibility factors and
molecular detection in liquid biopsies
Geok Wee Tan
Printing of this thesis was financially supported by University of Groningen and Graduate School of Medical Sciences, University of Groningen.
Cover: Geok Wee Tan and Khalisa Sulaiman Layout: Geok Wee Tan
© G.W. Tan 2021
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without prior written permission of the author.
Epstein‐Barr virus‐associated malignancies
Susceptibility factors and
molecular detection in liquid biopsies
PhD thesis
to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. C. Wijmenga and in accordance with the decision by the College of Deans. This thesis will be defended in public on 1 November 2021 at 11.00 hours byGeok Wee Tan
born in 1983 in Malaysia
Prof. J.H.M. van den Berg Prof. A. Diepstra
Co‐supervisor
Dr. L.P. TanAssessment Committee
Prof. P.G. Murray Prof. H.G.M. Niesters Prof. E.M.D. SchuuringParanymphs
Yujie Zhong Weiting Li
Contents
Chapter 1 Introduction 9
Chapter 2 The microenvironment in Epstein-Barr virus-associated malignancies
Pathogens 7, 1–23 (2018)
21
Chapter 3 HLA expression in relation to HLA type in classical Hodgkin lymphoma patients
Manuscript in preparation
45
Chapter 4 Human leukocyte antigen genotype and expression among nasopharyngeal carcinoma high-risk subpopulations in Malaysia
Manuscript in preparation
63
Chapter 5 Systematic comparison of plasma EBV DNA, anti-EBV antibodies and miRNA levels for early detection and prognosis of nasopharyngeal carcinoma
Int. J. Cancer 146, 2336–2347 (2020)
77
Chapter 6 A novel and non-invasive approach utilizing nasal washings for the detection of nasopharyngeal carcinoma
Int. J. Cancer 145, 2260–2266 (2019)
105
Chapter 7 Exploring the value of circulating tumor DNA as a disease biomarker in Hodgkin lymphoma patients
In progress
125
Chapter 8 Tumor profiling using circulating tumor DNA in Post-Transplant Lymphoproliferative Disorders
Manuscript in preparation
147
Chapter 9 Summary, discussion and future perspectives 165 Appendices Authors’ affiliations
Nederlandse samenvatting (Dutch summary)
178 180
