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Disease system analysis between complexity and (over) simplification Post, T.M.

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Post, T. M. (2009, December 1). Disease system analysis between complexity and (over) simplification. TIPharma, Division of Pharmacology, Schering-Plough, Leiden/Amsterdam Center for Drug Research, Faculty of Science, Leiden University. Retrieved from

https://hdl.handle.net/1887/14477

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Disease system analysis

between complexity and (over) simplification

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Disease system analysis

between complexity and (over) simplification

 

       

Proefschrift

     

ter verkrijging van 

de graad van doctor aan de Universiteit Leiden,  op gezag van rector magnificus prof. mr. P.F. van der Heijden, 

volgens besluit van het college voor promoties  te verdedigen op dinsdag 1 december 2009 

klokke 16.15 uur   

door     

Teun Matijs Post 

 

geboren te Utrecht  in 1977 

 

 

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Promotiecommissie   

Promotor:  

Prof. Dr. M. Danhof   

 

Co‐Promotor: 

Dr. T. Kerbusch   

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… and know tomorrow can't be depended on … Pearl Jam 

                                             

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appreciated. 

                                 

Publication of this thesis was financially supported by: 

Schering‐Plough, Oss, The Netherlands 

LAP&P Consultants BV, Leiden, The Netherlands 

Leiden/Amsterdam Center for Drug Research, Leiden University   

   

ISBN/EAN: 978‐90‐5335‐227‐4 

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  Section 1  General introduction 

1  Scope and outline    11 

2  Pharmacokinetic‐pharmacodynamic and disease progression    17  

  modeling 

 

Section 2  Development of disease system analysis methodologies 

3  Disease system analysis: basic disease progression models     39    in degenerative disease 

4  Extensions to the visual predictive check to facilitate model     65    performance evaluation  

 

Section 3  Application of disease system analysis in the investigation of  postmenopausal osteoporosis 

5  Bone physiology, disease and treatment: towards disease     91 

  system analysis in osteoporosis   

6  Characterization of a disease system for postmenopausal  147 

  osteoporosis   

 

Section 4  Summary, conclusions, general discussion, and perspectives  7  Modeling of changes in bone physiology during disease  193    and treatment based on the disease system analysis approach: 

  summary, conclusions, general discussion, and perspectives   

Samenvatting in het Nederlands  222 

Nawoord    232 

Curriculum Vitae  234 

List of Publications  235

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