University of Groningen
Towards new personalized treatment options for patients with genomically unstable tumors
van Gijn, Stephanie Elise
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Gijn, S. E. (2019). Towards new personalized treatment options for patients with genomically unstable tumors. Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn Processed on: 6-6-2019 Processed on: 6-6-2019 Processed on: 6-6-2019
Processed on: 6-6-2019 PDF page: 1PDF page: 1PDF page: 1PDF page: 1
Towards new personalized treatment options for patients
with genomically unstable tumors
531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn Processed on: 6-6-2019 Processed on: 6-6-2019 Processed on: 6-6-2019
Processed on: 6-6-2019 PDF page: 2PDF page: 2PDF page: 2PDF page: 2
The work described in this thesis was conducted at the Department of Medical Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
ISBN: 978-94-034-1720-2
ISBN (electronic version): 978-94-034-1719-6
Cover design: Ingrid J. van Gijn-Meijer (www.ingrid-meijer.nl) Lay-out design: Stephanie E. van Gijn & Ingrid J. van Gijn-Meijer Printing: Ipskamp Printing BV, Enschede
Printing of this thesis was supported by: - UMCG Graduate School of Medical Sciences - Stichting Werkgroep Interne Oncologie - University of Groningen
© Copyright 2019, S.E. van Gijn
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form without permission by the author.
531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn Processed on: 6-6-2019 Processed on: 6-6-2019 Processed on: 6-6-2019
Processed on: 6-6-2019 PDF page: 3PDF page: 3PDF page: 3PDF page: 3
Towards new personalized
treatment options for patients with
genomically unstable tumors
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 10 juli 2019 om 09.00 uur
door
Stephanie Elise van Gijn
geboren op 13 januari 1991 te 's-Gravenhage
531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn Processed on: 6-6-2019 Processed on: 6-6-2019 Processed on: 6-6-2019
Processed on: 6-6-2019 PDF page: 4PDF page: 4PDF page: 4PDF page: 4
Promotor
Prof. dr. M.A.T.M. van Vugt Copromotor Dr. R.S.N. Fehrmann Beoordelingscommissie Prof. dr. R. de Bree Prof. dr. W. Helfrich Prof. dr. F. Foijer Paranimfen Elly L. van der Veen Esméé Joosten
531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn Processed on: 6-6-2019 Processed on: 6-6-2019 Processed on: 6-6-2019
Processed on: 6-6-2019 PDF page: 5PDF page: 5PDF page: 5PDF page: 5
CONTENT
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 AppendixGeneral introduction & scope of the thesis
TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells
Oncogene, 2018
Elevated protein expression of TPX2 is positively associated with genomic instability in breast carcinomas
Analysis of replication stress and ATR inhibitor sensitivity in head and neck squamous-cell carcinomas
Data-driven prioritisation of antibody-drug conjugate targets in head and neck squamous cell carcinoma
Oral Oncol, 2018
Summarizing discussion & future perspectives
Dutch summary - Nederlandse samenvatting
Curriculum Vitae List op Publications Dankwoord/Acknowledgements 7 23 49 59 75 89 101 109
531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn 531746-L-bw-van Gijn Processed on: 6-6-2019 Processed on: 6-6-2019 Processed on: 6-6-2019
