ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis
Ye, D.
Citation
Ye, D. (2008, November 4). ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis. Retrieved from https://hdl.handle.net/1887/13220
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13220
LIST OF ABBREVIATIONS
36B4 Acidic ribosomal phosphoprotein PO ABC ATP-binding cassette transporter
Apo Apolipoprotein
BMT Bone marrow transplantation BSEP Bile salt efflux pump
CCR C-C chemokine receptor
CE Cholesteryl ester
CETP Cholesterol ester transfer protein CYP7A1 Cholesterol 7α-hydroxylase Cy3 Cyanine 3
EC Endothelial cell
EGFP Enhanced green-fluorescent protein FACS Fluorescent-activated cell sorting FITC Fluorescein 5-isothiocyanate
FXR Farnesoid X receptor
GAPDH Glyceraldehyde-3-phosphate dehydrogenase HDL High-density lipoprotein
HE Hematoxylin and eosin
HPRT Hypoxanthine-guanine phosphoribosyltransferase ICAM Intercellular adhesion molecule
IL Interleukin
KC Kupffer cell
KO Knockout
LCAT Lecithin:cholesterol acyltransferase
LDL Low-density lipoprotein
LDLR LDL receptor
LDLr-/-
LDL receptor deficient
LPL Lipoprotein lipase
LRP LDLr related protein
LPS Lipopolysaccharide
LXR Liver X receptor
MCP Monocyte chemoattractant protein
M-CSF Macrophage colony-stimulating factor
MMP Matrix metalloproteinase
WT Wild type
WTD Western-type diet
LIST OF PUBLICATIONS
Full papersYe D, Kraaijeveld AO, Grauss RW, van Vark-van der Zee LC, Willems SM, de Jager SC, Jauhiainen M, Atsma DE, Dallinga-Thie GM, Kuivenhoven JA, Hogendoorn PC, Biessen EA, Van Berkel TJ, Jukema JW, Van Eck M.
Reduced leukocyte cholesteryl ester transfer protein expression in acute coronary syndromes. Journal of Internal Medicine. 2008. In press.
Ye D, Hoekstra M, Out R, Meurs I, Kruijt JK, Hildebrand RB, Van Berkel TJ, Van Eck M. Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice.
Atherosclerosis. 2008; 196(2):650-658.
Ye D, Van Eck M, Hildebrand RB, Kar Kruijt J, de Haan W, Hoekstra M, Rensen PC, Ehnholm C, Jauhiainen M, Van Berkel TJ. Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice. Circ Res. 2007; 100(5):678-685.
Vikstedt R, Ye D, Metso J, Hildebrand RB, Van Berkel TJ, Ehnholm C, Jauhiainen M, Van Eck M. Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development.
Arterioscler Thromb Vasc Biol. 2007; 27(3):578-586.
Pennings M, Hildebrand RB, Ye D, Kunne C, Van Berkel TJ, Groen AK, Van Eck M. Bone marrow-derived multidrug resistance protein ABCB4 protects against atherosclerotic lesion development in LDL receptor knockout mice. Cardiovasc Res. 2007; 76(1):175-183.
Pennings M, Meurs I, Ye D, Out R, Hoekstra M, Van Berkel TJ, Van Eck M.
Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development. FEBS Lett. 2006; 580(23):5588- 5596.
binding cassette transporter A5 controls susceptibility to atherosclerosis in LDL receptor knockout mice. Manuscript in preparation.
Ye D, Hildebrand RB, Berbee JF, de Haan W, Van Berkel TJ, Rensen PC, Van Eck M. Cholesteryl ester transfer protein modulates LPS-induced TNF- α production and forms a host defense mechanism against systemic inflammation. Manuscript in preparation.
Ye D, Hildebrand RB, Hoekstra M, de Haan W, Van Berkel TJ, Rensen PC, Van Eck M. Effects of Torcetrapib, a potent CETP inhibitor, on the resistance to LPS in a murine model. Manuscript in preparation.
Published abstracts
Ye D, Hoekstra M, Out R, Meurs I, Kruijt JK, Hildebrand RB, Van Berkel TJ, Van Eck M. Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice.
Atherosclerosis suppl. 2007; 8:24.
Vikstedt R, Metso J, Ye D, Hildebrand RB, Van Berkel TJC., Ehnholm C, Jauhiainen M, Van Eck M. Deficiency of macrophage phospholipid transfer protein protects against atherosclerotic lesion development. Atherosclerosis suppl. 2007; 8:25.
Van Eck M, Ye D, Hildebrand RB, Kruijt JK, Hoekstra M, Ehnholm C, Jauhiainen. Importance of macrophage cholesteryl ester transfer protein (CETP) for determining serum cholesteryl ester transfer activity and atherosclerosis. Circulation. 2006;114:II-188.
Van Eck M, Ye D, Hildebrand RB, Kruijt JK, Jauhiainen M, Van Berkel TJ.
Cholesteryl ester transfer protein (CETP) production by macrophages promotes atherosclerotic lesion development. Atherosclerosis suppl. 2006;
7:152.
Vikstedt R, Metso J, Ye D, Hildebrand RB, Van Berkel TJC., Ehnholm C, Jauhiainen M, Van Eck M. Deficiency of macrophage phospholipid transfer protein protects against atherosclerotic lesion development. Atherosclerosis suppl. 2006; 7:320.
CURRICULUM VITAE
Dan Ye was born on November 22nd 1979 in the P.R. China. In 1998, she started her university education at Zhejiang University, Hangzhou, China, majoring in Biotechnology. From 2002 to 2003, she has majored in Genetics under the supervision of Prof. Dr. Mu-yuan Zhu in the college of Life Sciences, Zhejiang University, Hangzhou, China. In 2004, she was sponsored by the Chinese government to come to the Division of Biopharmaceutics of the Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, as a master student for one year, under the supervision of Prof. Dr. Theo J.C. Van Berkel and Dr. Miranda Van Eck. In 2005, she went back to China and obtained her Master’s degree in Zhejiang University, Hangzhou, China. Starting from September 2005, she has been working as a Ph.D. student in the Division of Biopharmaceutics of the LACDR, Leiden University, under the same supervision of Prof. Dr. Theo J.C. Van Berkel and Dr. Miranda Van Eck. During the 3-year Ph.D. student period, her research was mainly focused on the role of ATP-binding cassette transporters and lipid transfer proteins in macrophage cholesterol homeostasis and atherosclerosis. From September 1st 2008, she is appointed as a postdoctoral fellow at the Division of Biopharmaceutics on a project financed by the Netherlands Heart Foundation, entitled “The ABCs of Cardiovascular Disease: from the Pathogenesis of Atherosclerosis to Myocardial Ischemia”.
