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The handle http://hdl.handle.net/1887/20021 holds various files of this Leiden University dissertation.

Author: Lanz, Henriette Leonore

Title: Cancer-related targets sensed by apoptin Issue Date: 2012-10-24

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CV

131 Curriculum Vitae

Henriëtte Leonore Lanz was born on the 1st of October 1983 in Leidschendam. In 2001, she graduated from the gymnasium at College ‘t Loo in Voorburg. Following a year of working abroad she started her Life, Science & Technology studies at Leiden University and Delft University of Technology in 2002. After obtaining her Bachelor degree in 2005, she received her Master degree in 2008. During her final master internship at the department of Molecular Genetics of the Leiden Institute of Chemistry under supervision of Prof. M.

Noteborn and Dr. R. Zimmerman she was introduced to the research on apoptin. Following a succesful intership she was invited to continue her research in a PhD project entitled

‘Cancer-related targets sensed by apoptin’ supervised by Prof. M. Noteborn and Dr. C.

Backendorf. The results of this project are presented in this thesis. In March 2012 she started working for Explant Biotechnologies BV, a company focussed on the production and analysis of secondary plant metabolities.

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132

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List of Publications

133 List of Publications

Lanz HL, Florea BI, Noteborn MHM and Backendorf C (2012) Development and application of an in vitro apoptin kinase assay. Anal Biochem 421, 68-74.

Lanz HL, Suijker J, Noteborn MHM and Backendorf C (2012) Proteasomal insensitivity of apoptin in tumor cells. Biochem Biophys Res Commun 422, 169-173.

Lanz HL, Zimmerman RME, Brouwer J, Noteborn MHM and Backendorf C (2012) Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin. Manuscript submitted.

Zimmerman RME*, Peng D-J*, Lanz HL*, Zhang Y-H, Danen-van Oorschot AAAM, Qu S, Backendorf C and Noteborn MHM (2012) PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective killing. Cell Death Dis 3, e291. *contributed equally

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