University of Groningen
New catalytic reactions of (unsaturated) nitriles via metal-ligand cooperative activation of the
C≡N bond
Guo, Beibei
DOI:
10.33612/diss.136481036
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Guo, B. (2020). New catalytic reactions of (unsaturated) nitriles via metal-ligand cooperative activation of the C≡N bond. University of Groningen. https://doi.org/10.33612/diss.136481036
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Stellingen
Beibei Guo
1. Valuable experimental data always starts from a good design, the introductory essay would be an excellent starting point for any new PhD student.
2. Metal-ligand cooperative Milstein catalysts activate the nitrile C≡N bond to form a species with a more reactive C=N bond. Reducing the bond order makes many reactions easier. (Chapter 1)
3. Value can be found in most work in some way, as your reaction products could be (very close to) building blocks for natural products and bioactive molecules. (Chapter 2) 4. Sensitive organometallic chemistry often requires glovebox and/or Schlenk
techniques to avoid adventitious water and oxygen. Surprisingly, the presence of equimolar quantities of water may lead to unanticipated reactivity. (Chapter 3) 5. Expanding the group’s former research or even opening up new fields is most
chemists’ goal, whilst facing many potential difficulties and failures. Thus, collaboration with other groups in the field could be a shortcut to success.
6. The mechanism for the α-deuteration of aliphatic nitriles catalyzed by a ruthenium-MACHO complex, as proposed by Krishnakumar and Gunanathan, seems highly unlikely in view of the four-membered ruthenacycle intermediates. (V. Krishnakumar and C. Gunanathan, Chem. Commun., 2018, 54, 8705—8708.)
