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University of Groningen Towards an optimal clinical protocol for the treatment of moving targets with pencil beam scanned proton therapy Ribeiro, Cássia O.

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University of Groningen

Towards an optimal clinical protocol for the treatment of moving targets with pencil beam

scanned proton therapy

Ribeiro, Cássia O.

DOI:

10.33612/diss.126443635

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Ribeiro, C. O. (2020). Towards an optimal clinical protocol for the treatment of moving targets with pencil

beam scanned proton therapy. University of Groningen. https://doi.org/10.33612/diss.126443635

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(2)

Stellingen behorend bij het proefschrift

TOWARDS AN OPTIMAL CLINICAL PROTOCOL

FOR THE TREATMENT OF MOVING TARGETS

WITH PENCIL BEAM SCANNED

PROTON THERAPY

1. The use of multiple deformable image registration algorithms is a valuable strategy to reduce the uncertainty for inter- fractional dosimetric evaluation during lung cancer proton treatment. (This thesis)

2. Dosimetric errors induced by deformable image registration indicate the necessity to interpret individual 4D dose distri-butions for pencil beam scanned proton plans ideally with an error bar. (This thesis)

3. The establishment of optimal clinical protocols requires com-prehensive 4D evaluations of pencil beam scanned proton therapy for moving targets. (This thesis)

4. Although 3D robust optimised proton planning proved to be sufficient for most thoracic indications, accurate patient posi-tioning and adapting to anatomical variations over the course of treatment remain compulsory. (This thesis)

5. Clinically acceptable robust plans can be achieved for moving targets treated with Proteus®Plus, as well as with Proteus®One

proton scanning technologies. (This thesis)

6. Uncertainties in treating moving targets with protons are in-evitable. We need to know how to deal with them.

7. Intelligence is the ability to adapt to change. (Stephen Hawking) 8. A man is a success if he gets up in the morning and goes to

bed at night, and in between he does what he wants to do. (Bob Dylan)

9. It’s not the years in your life that count. It’s the life in your years. (Abraham Lincoln)

10. Happiness is not something readymade. It comes from your own actions. (Dalai Lama)

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