University of Groningen
Towards an optimal clinical protocol for the treatment of moving targets with pencil beam
scanned proton therapy
Ribeiro, Cássia O.
DOI:
10.33612/diss.126443635
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Ribeiro, C. O. (2020). Towards an optimal clinical protocol for the treatment of moving targets with pencil
beam scanned proton therapy. University of Groningen. https://doi.org/10.33612/diss.126443635
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Financial support for the publication of this thesis was kindly provided by:
• University of Groningen and the Graduate School of Medical Sciences
• University Medical Center Groningen • RaySearch Laboratories
Printed by: Eikon+ ISBN: 978-94-034-2749-2
ISBN (e-book): 978-94-034-2750-8
Copyright @C.Oraboni Ribeiro, Groningen, the Netherlands, 2020 All rights reserved. No part of this thesis may be reproduced in any form or by any means without prior permission of the author.
Towards an optimal clinical
protocol for the treatment of
moving targets with pencil beam
scanned proton therapy
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
dinsdag 9 juni 2020 om 11.00 uur
door
Cássia Oraboni Ribeiro
geboren op 7 januari 1991
te Curitiba, Brazilië
Promotores
Prof. dr. A.C. Knopf
Prof. dr. J.A. Langendijk
Copromotor
Dr. ir. E.W. Korevaar
Beoordelingscommissie
Prof. dr. S. Brandenburg
Prof. dr. B.W. Raaymakers
Prof. dr. J. Widder
CONTENTS
Chapter 1 General Introduction ...7
Chapter 2 Comprehensive 4D robustness evaluation for pencil beam scanned proton plans ...27
Chapter 3 Assessment of dosimetric errors induced by deformable image registration methods in 4D pencil beam scanned proton treatment planning for liver tumours ...45
Chapter 4 Towards the clinical implementation of intensity- modulated proton therapy for tho-racic indications: evaluation of 3D vs. 4D robust optimisation by means of patient and machine specific information...77
Chapter 5 Evaluation of intrinsic ‘rescanning’ (pulsed beam) versus scaled rescanning (continuous beam) for the treatment of moving targets with pencil beam scanned proton therapy ... 109
Chapter 6 Deformable image registration uncertainty for inter-fractional dose accumulation of lung can-cer proton therapy ... 129
Chapter 7 Discussion and future perspectives ... 159
Appendices ... 183 Summary ...185 Samenvatting ...191 Acronyms ... 197 Publications ... 199 Acknowledgements ...202 Curriculum Vitae ...211
