University of Groningen
Non canonical Wnt ligands and cytokine-driven myelopoiesis
Mastelaro de Rezende, Marina
DOI:
10.33612/diss.118670709
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Publication date:
2020
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Mastelaro de Rezende, M. (2020). Non canonical Wnt ligands and cytokine-driven myelopoiesis. University
of Groningen. https://doi.org/10.33612/diss.118670709
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Non canonical Wnt ligands and
cytokine-driven myelopoiesis
The studies described in this thesis were performed within the framework of Molecular Pharmacology Department of University of Groningen and Departamento de Bioquímica of Universidade Federal de São Paulo (UNIFESP), and it was partially supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), grants and scholarships numbers 2015/24464-1 and 2016/23787-4. Printing of this thesis was financially supported by: University Library and Graduate School of Science and Engineering (GSSE).
Paranymphs
Maria Bethania Rossi Piva bett_rossi@hotmail.com
Xinhui Wu x.wu@rug.nl
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Layout and cover design by Daniëlle Balk, persoonlijkproefschrift.nl Printed by Ipskamp Printing, proefschriften.net
ISBN: 978-94-034-2416-3 (e-book) ISBN: 978-94-034-2417-0 (print)
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Non canonical Wnt ligands and
cytokine-driven myelopoiesis
PhD thesis
to obtain the degree of PhD of the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans
and
to obtain the degree of PhD of Universidade Federal de
São Paulo (UNIFESP) on the autority of the Dean Prof. S. Soubhi Smaili and
in the accordance with the decision by the College of Deans
Double PhD degree
This thesis will be defended in public on Friday 13 March 2020 at 12:45 hours
by
Marina Mastelaro de
Rezende
born on 10 August 1989 in Jundiaí, Brazil
Supervisors Prof. R. Gosens Prof. E. J. Paredes-Gamero Assessment Committee Prof. A. R. Fock Prof. G. W. B. Colleoni Prof. B. N. Melgert Prof. P. Olinga
CONTENTS
1 General Introduction 92 Differential signaling requirements for the Cain IL-3 and GM-CSF-treated HSC and progenitor cells2+ and MEK/ERK pathways 39
3 Leukemia stem cell immunophenotyping - Tools for diagnostic, prognosis and therapeutics 61
4 WNT-5A/B signaling in hematopoiesis throughout life 83
5 Divergent effects of Wnt5b on IL-3- and GM-CSF-induced myeloid differentiation 109
6 Cell-intrinsic Wnt5 signaling reduces proliferative potential of ageing myeloid progenitors 135
7 Final Discussion 159 Appendices 175 Nederlandse Samenvatting 176 Acknowledgements 182 Curriculum Vitae 186 List of Publications 188
