University of Groningen
Non canonical Wnt ligands and cytokine-driven myelopoiesis
Mastelaro de Rezende, Marina
DOI:
10.33612/diss.118670709
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Mastelaro de Rezende, M. (2020). Non canonical Wnt ligands and cytokine-driven myelopoiesis. University of Groningen. https://doi.org/10.33612/diss.118670709
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Propositions
- IL-3 and GM-CSF signaling may not be as similar in their functional outcomes as currently considered (this thesis)
- IL-3 and GM-CSF share upstream intracellular signalling components, but differ downstream, mainly considering their impact on Ca2+ signalling (this thesis)
- Wnt5b exacerbates the differences intracellular signalling between IL-3 and GM-CSF (this thesis)
- Non-canonical Wnt signalling is associated to hematopoietic senescence (this thesis) - Understanding the mechanisms involved in cytokine-driven myelopoiesis and Wnt
signalling may provide tools for fighting myeloid imbalances observed with aging - Tight regulation of stem cell proliferation and differentiation is key in maintaining
physiological homeostasis, whilst avoiding cancer.
- As we take away the niche and physiological factors that govern the micro-environment in stem cell research to avoid interfering factors, we also take a step back from the “real world”
- Anytime a doubt is clarified, another 10 appear
- “The most exciting phrase to hear in science, the one that heralds new discoveries, is not ‘Eureka!’ but ‘That’s funny…’” (Isaac Asimov)
