University of Groningen
Regenerative Pharmacology for COPD
Wu, Xinhui
DOI:
10.33612/diss.157528459
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wu, X. (2021). Regenerative Pharmacology for COPD. University of Groningen. https://doi.org/10.33612/diss.157528459
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Regenerative Pharmacology
for COPD
The studies described in this thesis were performed within the framework of the Groningen University Institute for Drug Exploration (GUIDE), the Groningen Research Institute for Pharmacy (GRIP), the Groningen Research Institute for Asthma and COPD (GRIAC) and the China Scholarship Council (CSC).
Printing of this thesis was financially supported by University of Groningen (RUG)
Graduate School of Science and Engineering (GSSE) Paranymphs
Mariska van den Berg Sophie Bos
Thesis cover idea: Xinhui Wu
Layout and design: Bregje Jaspers | ProefschriftOntwerp.nl Printing: ProefschriftMaken | www.proefschriftmaken.nl
Regenerative Pharmacology
for COPD
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Monday 8 March 2021 at 11.00 hours
by
Xinhui Wu
born on 8 March 1990
in Jilin, China
Supervisors
Prof. R. Gosens
Prof. M. Schmidt
Assessment Committee
Prof. H.I. Heijink
Prof. P.S. Hiemstra
Prof. P. Hansbro
Contents
Chapter 1 General Introduction
Chapter 2 Mouse Lung Tissue Slice Culture
Chapter 3 Mesenchymal WNT-5A/5B signaling Represses Lung
Alveolar Epithelial Progenitors
Chapter 4 Rho-kinase 1/2 inhibition Prevents TGF-β-induced
Effects on Pulmonary Remodeling and Repair
Chapter 5 Diesel Exhaust Particles Distort Functional Interactions
between Lung Epithelial Progenitors and their Fibroblast Niche
Chapter 6 PGE2 and PGI2 Analogues Restore Cigarette
Smoke-induced Functional Defects of Lung Epithelial Progenitors
Chapter 7 General Discussion
Appendix English summary
Nederlandse samenvatting Acknowledgement Curriculum vitae List of publications 9 29 49 75 105 127 16 181 185 189 199 201
XINHUI
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