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The astrocytic cytoskeleton: Unravelling the role of GFAPδ
Moeton, M.
Publication date
2014
Document Version
Final published version
Link to publication
Citation for published version (APA):
Moeton, M. (2014). The astrocytic cytoskeleton: Unravelling the role of GFAPδ. Boxpress.
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The astrocytic cytoskeleton:
Unravelling the role of GFAPδ
by
Martina Moeton
2014
The research for this thesis was carried out at the Netherlands Institute for Neuroscience, an Institute of the Royal Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands. This research described here was financially supported by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO-ALW-VICI).
Publication of this thesis was financially supported by the Netherlands Institute for Neuroscience and the Graduate School Neurosciences Amsterdam Rotterdam (ONWAR).
Layout by: Dr. Carlyn Martina-Mamber
Cover art provided by: Mgr. Miriana Materáková Printed by: Proefschriftmaken.nl || Uitgeverij BOXPress Published by: Uitgeverij BoxPress, ‘s-Hertogenbosch
Copyright © 2014 by Martina Moeton. All rights reserved. No part of this book may be reproduced, transmitted in any form or by any means, or stored in a retrieval system, without prior permission of the author.
The astrocytic cytoskeleton: Unravelling the role of GFAPδ
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam,
op gezag van de Rector Magnificus
prof. Dr. D.C. van den Boom
ten overstaan van een door het college voor promoties
ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 24 oktober 2014, te 10:00 uur
door
Martina Moeton
Faculteit der Natuurwetenschappen, Wiskunde en Informatica Promotor:
Co-promotor:
Overige leden:
Prof. Dr. E.M. Hol Dr. M.E. van Strien
Prof. Dr. P.J. Lucassen Prof. Dr. H.E. de Vries Prof. Dr. G.H. Koenderink Prof. Dr. S. Etienne-Manneville Dr. E.A.J. Reits
Table of Contents
Chapter 1. General Introduction
The GFAP splice variant GFAPδ: From molecule to function
M. Moeton, M.E. van Strien, E.M. Hol
9 - 37
Chapter 2.
Differential role for Glial Fibrillary Acidic Protein isoforms in cell proliferation and morphology of human astrocytes
M. Moeton, J.A. Sluijs, V. van der Meer, O.M.J.A. Stassen, M.E. van Strien, E.M. Hol
41 - 70
Chapter 3.
Assembly compromised GFAPδ has a decreased subunit exchange rate in an intermediate filament network
M. Moeton, L.J. Kluivers, F.M.G. Cornelissen, J.A. Sluijs, E.A.J. Reits, M.E. van Strien, E.M. Hol
73 - 96
Chapter 4.
Reintroduction of specific GFAP isoforms into the adult GFAP KO mouse subventricular zone
C. Mamber, M. Moeton, J.A. Sluijs, L. Kooijman, M. Pekny, E.M. Hol
99 - 122
Chapter 5.
Silencing GFAP isoforms in astrocytoma cells disturbs laminin dependent motility and cell adhesion
M. Moeton, R. Kanski , O.M.J.A. Stassen, J.A. Sluijs, D. Geerts, P. van Tijn, G. Wiche, M.E. van Strien, E.M. Hol
125 - 152
Chapter 6. General Discussion 155 - 178
7. Summary 182 - 184
8. Samenvatting 186 - 188
9. Dankwoord 190 - 193
10. List of Publications 194
