University of Groningen
Studying cardiac diseases using human stem cell-derived cardiomyocytes
Hoes, Martinus Franciscus Gerardus Adrianus
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hoes, M. F. G. A. (2019). Studying cardiac diseases using human stem cell-derived cardiomyocytes.
Rijksuniversiteit Groningen.
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Studying cardiac diseases using human
stem cell-derived cardiomyocytes
© 2019 Martijn Hoes
Copyright of each chapter is with the publisher of the journal in which the work has appeared. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without prior permission
Cover illustration: Lysanne Jorna (Lysannejorna@msn.com)
Vifor Pharma
Graduate School of Medical Sciences (RUG)
Financial support by the Dutch Heart Foundation for the publication of this thesis is grate-fully acknowledged. The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2012T047).
Gedrukte versie: 978-94-034-1405-8 Digitale versie: 978-94-034-1404-1
Studying cardiac diseases using human stem cell-derived cardiomyocytes Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 20 maart 2019 om 14.30 uur door
Martinus Franciscus Gerardus Adrianus Hoes
geboren op 2 september 1988 te Roermond
Studying cardiac diseases using human
stem cell-derived cardiomyocytes
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 20 maart 2019 om 14.30 uur
door
Martinus Franciscus Gerardus Adrianus Hoes
geboren op 2 september 1988
Promotor
Prof. dr. P. van der Meer
Copromotor Dr. N. Bömer Beoordelingscommissie Prof. dr. F. Foijer Prof. dr. R. Passier Prof. dr. J. Roos-Hesselink Paranimfen Dr. N. Grote Beverborg Dr. K. Theodorou
Voor Joy Hoes, omdat elke dag telt.
ContentS
Chapter 1 Introduction and aims 9
PARt I
Chapter 2 The current state of human in vitro cardiac disease modeling:
a focus on gene editing and tissue engineering
21
Chapter 3 Iron deficiency impairs contractility of human cardiomyocytes
through decreased mitochondrial function
41
Chapter 4 Modeling human cardiac hypertrophy in stem cell-derived
cardiomyocytes
71
PARt II
Chapter 5 Peripartum cardiomyopathy: an overview 107
Chapter 6 Circulating cathepsin D in Heart Failure: a translational approach. 119
Chapter 7 Sterol metabolism is differentially regulated in human induced pluripotent stem cell-derived cardiomyocytes of peripartum cardiomyopathy patients.
139
Chapter 8 General discussion and future perspectives 161
Appendices Dutch Summary 177
Curriculum Vitae 185
Publication list 187
