University of Groningen
Studying cardiac diseases using human stem cell-derived cardiomyocytes
Hoes, Martinus Franciscus Gerardus Adrianus
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hoes, M. F. G. A. (2019). Studying cardiac diseases using human stem cell-derived cardiomyocytes.
Rijksuniversiteit Groningen.
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Stellingen behorende bij het proefschrift:
Studying cardiac diseases using human stem cell-derived cardiomyocytes
1. In vitro disease models need to be employed to unravel cell-autonomous pathophysiological mechanisms - This thesis
2. Induced pluripotent stem cells are well suited to study diseases with a multi-factorial cause that cannot be attributed to a single mutation - This thesis
3. Iron deficiency reversibly impairs mitochondrial function and contractility - This thesis
4. Inhibition of the SP6-FSTL3 pathway prevents hypertrophic remodeling of human cardiomyocytes in response to cyclic stretch - This thesis
5. Increased levels of circulating cathepsin D are not exclusive to peripartum cardiomyopathy, but resemble a generic stress response in heart failure patients - This thesis
6. Aberrant cardiomyocyte sterol and lipid metabolism is a key pathway in the pathophysiology of peripartum cardiomyopathy - This thesis
7. Reason is not automatic. Those who deny it cannot be conquered by it - Ayn Rand
8. All generalizations are false - Mark Twain
9. There is nothing efficient about innovation - Simon Sinek 10. When the rules are defined, your only option is to play the game
