University of Groningen
PET methodology in rat models of Parkinson’s disease
Schildt, Anna
DOI:
10.33612/diss.125440245
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Schildt, A. (2020). PET methodology in rat models of Parkinson’s disease. University of Groningen. https://doi.org/10.33612/diss.125440245
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
PET Methodology in Rat Models of
Parkinson’s Disease
The research reported in this thesis was carried out at the Department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen, Groningen, The Netherlands and at the PET-MRI Imaging Center of the University of British Columbia, Vancouver, British Columbia, Canada.
Financial support for the research reported in the thesis was obtained by scholarships from the Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada, the Research School of Behavioral and Cognitive Neurosciences (BCN), University of Groningen, Groningen, The Netherlands, and the University Medical Center Groningen, Groningen, The Netherlands.
Printing of this thesis was financially supported by the Library of the University of Groningen and the Research School of Behavioral and Cognitive Neurosciences.
Cover Design: Anna Schildt Printed by: Ridderprint
ISBN: 978-94-034-2627-3 (hardcopy)
ISBN: 978-94-034-2626-6 (electronic version)
Dissertation of the University of Groningen, Groningen, The Netherlands
PET Methodology in Rat Models of
Parkinson’s Disease
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Wednesday 27 May 2020 at 9.00 hours
by
Anna Schildt
born on 12 October 1987
in Magdeburg, Germany
Supervisors
Prof. E. F. J. de Vries
Prof. V. Sossi
Prof. R. A. J. O. Dierckx
Co-supervisor
Dr.
J. Doorduin
Assessment committee
Prof. T. van Laar
Prof. A. A. Lammertsma
Prof. R. Boellaard
Paranymphs
Elisabeth Pfaehler
Lara García Varela
Contents
Chapter 1. Introduction……….. 9
Chapter 2. Quantification of the Acetylcholinesterase Radioligand [11C]-PMP in Rats..………... 33
Chapter 3. Modeling of [18F]-FEOBV Pharmacokinetics in Rat Brain……….. 65
Chapter 4. Effect of Dopamine D2 Receptor Antagonists on [18F]-FEOBV Binding………... 91
Chapter 5. Exercise Does Not Affect the Cholinergic Activity in a Striatal 6-OHDA Rat Model of Parkinson’s Disease……. 115
Chapter 6. Single Inflammatory Trigger Leads to Neuroinflammation in LRRK2 Rodent Model without Degeneration of Dopaminergic Neurons……….... 141
Chapter 7. Summary……….. 181
Chapter 8. Future Perspective………. 191
Chapter 9. Nederlandse Samenvatting……….. 211
