University of Groningen
PET methodology in rat models of Parkinson’s disease
Schildt, Anna
DOI:
10.33612/diss.125440245
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Schildt, A. (2020). PET methodology in rat models of Parkinson’s disease. University of Groningen.
https://doi.org/10.33612/diss.125440245
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Propositions belonging to the dissertation
PET Methodology in Rat Models of Parkinson’s Disease
by
Anna Schildt
1. For unbiased quantification of PET data, an in-depth evaluation of the radioligand in the species under investigation is necessary before its use in this particular species. (Chapter 2 – 4)
2. Baseline measurements to investigate possible differences between individuals before an intervention are crucial. (Chapter 6)
3. Parkinson’s disease is a multifactorial disease and therefore increasing the construct validity of an animal model by exposure to more than one disease trigger should result in increased face and predictive validity of the model. (Chapter 6)
4. To reflect the genetic diversity of humans, a broader range of animal strains or even different animal species should be used for disease models.
5. Before conclusions can be drawn about human diseases from an animal model, the limitations of the animal model need to be addressed. (Chapter 5 – 6)
6. Evaluation of the interaction of neurotransmitter systems in Parkinson’s disease patients will increase our knowledge of non-motor symptoms, lead to the development of new treatments and, consequently, improve quality of life for Parkinson’s disease patients and their caregivers.
7. Agatha Christie’s description of Hercule Poirot also applies to scientists: “Hercule Poirot's methods are his own. Order and method, and 'the little gray cells'.”
8. Marie Curie’s statement about the fear of radioactivity also applies to the current COVID-19 pandemic “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.”
9. In a post-truth world, in which public figures and parts of society prioritize emotions over facts, scientists and the media should communicate research in an understandable, honest and relatable way to the public to allow everyone to draw conclusions based on scientific evidence rather than fake news and feelings.
