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Muscle matters! Recognizing the clinical relevance of the ageing muscle
Reijnierse, E.M.
2017
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Reijnierse, E. M. (2017). Muscle matters! Recognizing the clinical relevance of the ageing muscle.
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Muscle matters!
Recognizing the clinical relevance of the ageing muscle
This thesis was prepared within the EMGO Institute for Health and Care Research. Financial support for the printing of this thesis has been kindly provided by Nutricia Research, McRoberts B.V. and L.M. Meijers B.V.
Cover: Mayla Schoorl
Layout: Esmee Reijnierse
Printed by: GVO drukkers & vormgevers B.V.
ISBN: 979 90 5383 246 2
© 2017, E.M. Reijnierse, Amsterdam, The Netherlands
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, electronically, mechanically, including photocopying, recording or by any information storage and retrieval system, without written permission of the author.
VRIJE UNIVERSITEIT
Muscle matters!
Recognizing the clinical relevance of the ageing muscle
ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan
de Vrije Universiteit Amsterdam, op gezag van de rector magnificus
prof.dr. V. Subramaniam, in het openbaar te verdedigen ten overstaan van de promotiecommissie
van de Faculteit der Geneeskunde op maandag 3 april 2017 om 15.45 uur
in de aula van de universiteit, De Boelelaan 1105
door
This thesis was prepared within the EMGO Institute for Health and Care Research. Financial support for the printing of this thesis has been kindly provided by Nutricia Research, McRoberts B.V. and L.M. Meijers B.V.
Cover: Mayla Schoorl
Layout: Esmee Reijnierse
Printed by: GVO drukkers & vormgevers B.V.
ISBN: 979 90 5383 246 2
© 2017, E.M. Reijnierse, Amsterdam, The Netherlands
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, electronically, mechanically, including photocopying, recording or by any information storage and retrieval system, without written permission of the author.
VRIJE UNIVERSITEIT
Muscle matters!
Recognizing the clinical relevance of the ageing muscle
ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan
de Vrije Universiteit Amsterdam, op gezag van de rector magnificus
prof.dr. V. Subramaniam, in het openbaar te verdedigen ten overstaan van de promotiecommissie
van de Faculteit der Geneeskunde op maandag 3 april 2017 om 15.45 uur
in de aula van de universiteit, De Boelelaan 1105
door
promotor: prof.dr. A.B. Maier copromotoren: dr. C.G.M. Meskers
dr. M.A.E. de van der Schueren dr. M.C. Trappenburg
Contents
Chapter 1 General introduction 7
Chapter 2 The impact of different diagnostic criteria on the prevalence of sarcopenia
in healthy elderly participants and geriatric outpatients
17
Chapter 3 Common ground? The concordance of sarcopenia and frailty definitions 31
Chapter 4 Assessment of maximal handgrip strength: how many attempts are
needed?
49
Chapter 5 The association between parameters of malnutrition and diagnostic
measures of sarcopenia in geriatric outpatients
71
Chapter 6 Serum albumin and muscle measures in a cohort of healthy young and old
participants
91
Chapter 7 Instrumented assessment of physical activity is associated with muscle
function but not with muscle mass in a general population
107
Chapter 8 Lack of knowledge and availability of diagnostic equipment hinder the
diagnosis of sarcopenia and its management
127
Chapter 9 General discussion 147
Summary in Dutch – Nederlandse Samenvatting 158
Acknowledgements – Dankwoord 169
Publication list 173
