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Drug effects on melanoma

Koomen, E.R.

Citation

Koomen, E. R. (2010, September 15). Drug effects on melanoma. Retrieved from https://hdl.handle.net/1887/15947

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/15947

Note: To cite this publication please use the final published version (if applicable).

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DRUG EFFECTS

MELANOMA ON

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The research presented in this thesis was performed at the department of

Clinical Pharmacy and Toxicology of Leiden University Medical Center, The Netherlands.

The printing of this thesis was financially supported by: AZL Onderzoeks- en Ontwikkelingskrediet (OOK) Apotheek.

Cover design and layout by: In Zicht Grafisch Ontwerp, Arnhem Printed by: Ipskamp Drukkers, Enschede

ISBN 978-90-9025454-8

© Els Koomen 2010

All rights reserved. No parts of this publication may be reproduced, stored in a retrieval system of any nature, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior written permission of the publisher.

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DRUG EFFECTS ON MELANOMA

Proefschrift

ter verkrijging van de graad van Doctor aan de Universiteit Leiden op gezag van de rector magnificus prof. mr. P.F. van der Heijden,

volgens besluit van het College van Decanen te verdedigen op 15 september 2010

klokke 15:00 uur

door

Els Koomen

geboren op 20 december 1976 te Nijmegen

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Promotor Prof. Dr. H.J. Guchelaar

Copromotor

Dr. T.E.C. Nijsten, Universiteit Erasmus MC Rotterdam

Overige leden

Prof. Dr. J.P. Vandenbroucke Mw Prof. Dr. W. Bergman

Prof. Dr. A.C.G. Egberts, Universiteit Utrecht

Mw Dr. E. de Vries, Universiteit Erasmus MC Rotterdam Dr. R.M.C. Herings, Universiteit Erasmus MC Rotterdam

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The essence of life is statistical improbability on a colossal scale.

– Richard Dawkins

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1 Introduction and scope of the thesis 9 2 Epidemiology of Extracutaneous Melanoma in The Netherlands 19

Cancer Epidemiol Biomarkers Prev 2010, 19(6),1453-1459

3 Burden of disease in Dutch melanoma patients, 1989-2006 35

Submitted

4 Chemoprevention of melanoma: chemopreventive drugs and their 51 pharmacological mechanism of action, efficacy, safety and tolerability

Submitted

5 Statin effects on the incidence, Breslow thickness and time 107 to metastasis of cutaneous melanoma

European Journal of Cancer 2007, 43(17), 2580-2589

6 Use of Non Steroidal Anti Inflammatory Drugs and the incidence 131 of cutaneous melanoma: a population-based case control study

Journal of Investigative Dermatology 2009, 129(11), 2620-2627

7 Angiotensin-Converting Enzyme Inhibitors and Angiotensin 151 Receptor Blockers and their effects on the Incidence of

Cutaneous Melanoma

Cancer Epidemiology 2009, 33(5), 391-395

8 Estrogens, oral contraceptives and hormonal replacement 165 therapy, increase the incidence of cutaneous melanoma:

a population-based case control study Annals of Oncology 2009, 20(2), 358-364

9 Does use of estrogens decrease Breslow thickness of melanoma 181 of the skin?

Melanoma Research 2009, 19(5), 327-332

10 General discussion, future perspective & conclusions 195

11 Summary en Nederlandse samenvatting 225

Dankwoord 241

Publicatielijst 243

Curriculum vitae 245

Contents

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