University of Groningen
Celiac disease
Zorro Manrique, Maria Magdalena
DOI:
10.33612/diss.122712049
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zorro Manrique, M. M. (2020). Celiac disease: From genetic variation to molecular culprits. University of
Groningen. https://doi.org/10.33612/diss.122712049
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1. By combining eQTL analysis, gene prioritization tools and in vitro methods, one can identify potential causal genes and the main biological pathways that underlie celiac disease pathogenesis (Chapters 2 and 3).
2. Celiac disease genetics affects both the immune system and the epithelial layer, thereby disturbing homeostasis of the intestinal barrier (Chapters 2 and 3). 3. LPP is not only a cell–cell interaction protein, it is also an immune regulator in
intestinal epithelial cells (Chapter 3).
4. Reduced expression of LPP in the intestinal mucosa of celiac disease patients may lead to enhanced recruitment and activation of immune cells in response to gluten (Chapter 3).
5. A novel lncRNA, RP11-291B21.2, regulates the balance between activation and quiescence of intraepithelial cytotoxic lymphocytes (IE-CTLs) and could hereby be involved in limiting intestinal tissue damage (Chapter 6).
6. Innate immune cells and intestinal epithelial cells deliver essential signals (tissue alarmins) that unleash the killing properties of IE-CTLs, the effector cells in celiac disease (Chapter 4).
7. Clusters of genes associated with immune-mediated diseases, including those associated with celiac disease, converge on the interferon gamma (IFNg) signaling pathway. The identification of the master regulators (e.g. TRAFD1) and main cell types (e.g. IE-CTLs) involved in this biological pathway represent an opportunity for developing novel therapeutic interventions (Chapters 3 and 4).
8. “Yet the paradox of science is that every answer breeds at least two new questions. More tools, more answers, ever more questions.” - Kevin Kelly
9. “It always seems impossible until it’s done.” - Nelson Mandela
10. “Many of life’s failures are people who did not realize how close they were to success when they gave up.” - Thomas A. Edison
