University of Groningen Celiac disease Zorro Manrique, Maria Magdalena

University of Groningen

Celiac disease

Zorro Manrique, Maria Magdalena

DOI:

10.33612/diss.122712049

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Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Zorro Manrique, M. M. (2020). Celiac disease: From genetic variation to molecular culprits. University of

Groningen. https://doi.org/10.33612/diss.122712049

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Celiac disease:

from genetic variation to molecular culprits

Maria Magdalena Zorro Manrique

Celiac disease: from genetics variation to molecular culprits.

ISBN: 978-94-034-2558-0 (e-book) ISBN: 978-94-034-2559-7 (print)

Copyright © 2020, María Magdalena Zorro Manrique

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means - electronic, mechanically, by

photocopying, recording or otherwise - without express written permission form the author and, when appropriate, the publisher holding the copyrights of the published articles. Cover and layout design by Claudia González Arévalo

claudia@tangroop.com Printed by ProefschriftMaken https://www.proefschriftmaken.nl

Celiac disease:

from genetic variation to molecular culprits

PhD thesis

to obtain the degree of PhD at the

University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga

and in accordance with

the decision by the College of Deans.

This thesis will be defended in public on

Wednesday 22 April 2020 at 11.00 hours

by

Maria Magdalena Zorro Manrique

born on 4 September

1979

in Puerto Wilches, Colombia

Supervisors

Prof. C. Wijmenga

Dr. S. Withoff

Co-supervisor

Dr. I.H. Jonkers

Assessment Committee

Prof. A. van den Berg

Prof. J.D. Laman

Prof. F. Koning

Paranymphs:

Kieu T.T. Le

Joram Mooiweer

Chapter 1

General introduction.

₉

Chapter 2

The role of celiac disease associated protein LPP in

intestinal barrier function.

21

Chapter 3

Systematic prioritization of candidate genes in disease

loci identifies TRAFD1 as a master regulator of IFNg

signalling in celiac disease.

43

Chapter 4

Tissue alarmins and adaptive cytokine induce dynamic

and distinct transcriptional responses in tissue-resident

intraepithelial cytotoxic T lymphocytes.

77

Chapter 5

Small and long regulatory RNAs in the immune system

and immune diseases.

107

Chapter 6

Knockdown of the lncRNA RP11-291B21.2 interferes

with the activation of CD8

_{T cells.}

143

Chapter 7

Discussion.

₁₇₁

Appendices

Summary.

₁₈₉

Sammenvatting

₁₉₃

Resumen.

₁₉₇

Acknowledgements.

₂₀₁

Curriculum Vitae.

₂₀₄

List of publications.

₂₀₅