University of Groningen
Enhancing vaccination efficacy by application of in vitro preselected dietary fibers and lactic
acid bacteria
Lépine, Alexia
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Lépine, A. (2018). Enhancing vaccination efficacy by application of in vitro preselected dietary fibers and
lactic acid bacteria. University of Groningen.
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PROPOSITIONS
BE LO N GIN G TO TH I S DI SSE RTATI O N
Enhancing vaccination efficacy by application of
in vitro preselected dietary fibers and lactic acid bacteria
1. Specific lactic acid bacteria support protection against Salmonella infections without impacting fecal microbiota (this thesis) 2. Tight-junction regulation by dietary components goes beyond
expression of genes commonly or conventionally investigated implying that it might have been incorrectly concluded that some dietary components do not influence gut barrier function (this thesis) 3. Synbiotics can exert synergistic direct immune effects independent of
synergistic microbiota effects (this thesis)
4. Long-chain inulin type fructans is unable to support vaccination of piglets although it supports their immune development (this thesis) 5. Natural infections concomitantly occurring during a vaccination
protocol increase protection of the animals against later infections (this thesis)
6. Microbiota changes induced by dietary intervention can only be measured during dysbiosis periods (this thesis)
7. Animal experiments during Christmas holidays work out as well as Santa is real
8. Skills developed when playing ‘improvisational theater’ can come in handy during research projects
9. Doing a PhD within a consortium teaches a lot more than just science
