University of Groningen
Enhancing vaccination efficacy by application of in vitro preselected dietary fibers and lactic
acid bacteria
Lépine, Alexia
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Publication date: 2018
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Lépine, A. (2018). Enhancing vaccination efficacy by application of in vitro preselected dietary fibers and lactic acid bacteria. University of Groningen.
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Enhancing vaccination efficacy
by application of in vitro preselected
dietary fibers and lactic acid bacteria
This research was supported by the Dutch Ministry of Economic Affairs under the TKI Agrifood, project AF12203 ‘CarboHealth’ within the framework of the Carbohydrate Competence Center (CCC, www.cccresearch.nl).
Layout Célia Lépine
Cover design/illustration C. Lépine, A. Bachmann, C. Petermann
Printed by ProefschriftMaken
www.proefschriftmaken.nl
ISBN 978-94-034-1134-7 (print)
978-94-034-1133-0 (digital)
© Copyright 2018 Alexia Floriane Pauline Lépine, Groningen, The Netherlands All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
Enhancing vaccination effi
cacy
by application of in vitro preselected
dietary fi bers and lactic acid bacteria
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnifi cus Prof. E. Sterken
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Wednesday 17 October 2018 at 11.00 hours
by
Alexia Floriane Pauline Lépine
born on 5 June 1988
Supervisors
Prof. P. de Vos
Prof. H.J. Wichers
Assessment Committee
Prof. G. Dijkstra
Prof. L. Dijkhuizen
Prof. H. Schols
Paranymphs
Dr. E. Zaccaria
S. Figueroa-Lozano
Table of contents
Chapter 1 General introduction
Rational and outline of the thesis
Chapter 2 Lactobacillus acidophilus attenuates Salmonella-induced
stress of epithelial cells by modulating tight-junction genes and cytokine responses
Chapter 3 Synbiotic effects of the dietary fiber long-chain inulin
and probiotic Lactobacillus acidophilus W37 can be caused by direct, synergistic stimulation of immune Toll-like receptors and dendritic cells
Chapter 4 Combined dietary supplementation of long chain inulin
and Lactobacillus acidophilus in neonate piglets supports
oral vaccination efficacy against Salmonella Typhimurium
Chapter 5 Impact of oral Salmonella vaccination and dietary interventions
on fecal microbiota development of neonatal piglets
Chapter 6 Higher chain length distribution in debranched type-3 starches
increases TLR signaling and supports dendritic cell cytokine production
Chapter 7 General discussion
Appendices
Abbreviations Summary
Nederlandse samenvattig Acknowledgments
About the author Author Affiliations Publications list 9 27 51 79 109 149 195 239 273
